(Q36302109)

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Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

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molecular chaperones

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author name string

Nupur Dasgupta

1

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Europe PubMed Central

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13 August 2017

You-Hai Xu

2

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13 August 2017

Ronghua Li

3

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13 August 2017

Yanyan Peng

4

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13 August 2017

Manoj K Pandey

5

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13 August 2017

Stuart L Tinch

6

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Europe PubMed Central

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13 August 2017

Benjamin Liou

7

1 reference

Europe PubMed Central

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13 August 2017

Venette Inskeep

8

1 reference

Europe PubMed Central

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13 August 2017

Wujuan Zhang

9

1 reference

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13 August 2017

Kenneth D R Setchell

10

1 reference

Europe PubMed Central

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13 August 2017

Mehdi Keddache

11

1 reference

Europe PubMed Central

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13 August 2017

Gregory A Grabowski

12

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13 August 2017

Ying Sun

13

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13 August 2017

publication date

29 September 2015

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13 August 2017

Human Molecular Genetics

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13 August 2017

24

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Europe PubMed Central

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13 August 2017

24

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Europe PubMed Central

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13 August 2017

7031-7048

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Multiple pathogenic proteins implicated in neuronopathic Gaucher disease mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

1 reference

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30 September 2017

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models

1 reference

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30 September 2017

Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction

1 reference

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30 September 2017

Selective distribution and dynamic modulation of miRNAs in the synapse and its possible role in Alzheimer's Disease

1 reference

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30 September 2017

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

1 reference

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30 September 2017

Gaucher disease: transcriptome analyses using microarray or mRNA sequencing in a Gba1 mutant mouse model treated with velaglucerase alfa or imiglucerase

1 reference

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30 September 2017

Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases

1 reference

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30 September 2017

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

1 reference

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30 September 2017

Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease

1 reference

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30 September 2017

Long-term potentiation: peeling the onion

1 reference

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Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

1 reference

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30 September 2017

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1 reference

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30 September 2017

Regulation and misregulation of Eph/ephrin expression

1 reference

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30 September 2017

miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.

1 reference

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30 September 2017

Molecular network of microRNA targets in Alzheimer's disease brains

1 reference

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30 September 2017

MicroRNA expression profiling reveals miRNA families regulating specific biological pathways in mouse frontal cortex and hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

1 reference

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30 September 2017

Type 2 Gaucher disease: phenotypic variation and genotypic heterogeneity

1 reference

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30 September 2017

Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons

1 reference

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30 September 2017

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

1 reference

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30 September 2017

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function

1 reference

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30 September 2017

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

1 reference

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30 September 2017

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

MicroRNA expression in the adult mouse central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4654057

30 September 2017

Murine models of acute neuronopathic Gaucher disease

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Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

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30 September 2017

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

1 reference

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Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus

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30 September 2017

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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Analysis and classification of 304 mutant alleles in patients with type 1 and type 3 Gaucher disease

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A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis.

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

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The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

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Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

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1 reference

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12 December 2020

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10.1093/HMG/DDV404

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

13 August 2017

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