(Q36304018)

13 August 2017

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title

Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer (English)

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13 August 2017

Eric B Haura

1

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13 August 2017

James Turkson

series ordinal

2

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13 August 2017

Richard Jove

series ordinal

3

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13 August 2017

publication date

1 June 2005

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Nature Clinical Practice Oncology

13 August 2017

published in

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13 August 2017

volume

2

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13 August 2017

issue

6

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13 August 2017

page(s)

315-324

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STATs and gene regulation

13 August 2017

cites work

1 reference

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7 January 2021

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

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7 January 2021

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

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7 January 2021

The STATs of cancer--new molecular targets come of age

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7 January 2021

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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7 January 2021

Cytoplasmic transport of Stat3 by receptor-mediated endocytosis

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7 January 2021

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

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7 January 2021

A family of cytokine-inducible inhibitors of signalling

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7 January 2021

Specific inhibition of Stat3 signal transduction by PIAS3

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7 January 2021

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

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7 January 2021

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

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7 January 2021

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

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7 January 2021

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

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7 January 2021

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

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7 January 2021

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

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7 January 2021

Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

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7 January 2021

STAT3 is required for the gp130-mediated full activation of the c-myc gene

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7 January 2021

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

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7 January 2021

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

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7 January 2021

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

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7 January 2021

A critical role for Stat3 signaling in immune tolerance

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7 January 2021

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

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7 January 2021

Stat3 regulates genes common to both wound healing and cancer

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7 January 2021

Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

1 reference

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7 January 2021

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

1 reference

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7 January 2021

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

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7 January 2021

Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade

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7 January 2021

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

1 reference

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7 January 2021

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice

1 reference

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7 January 2021

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma

1 reference

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7 January 2021

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

1 reference

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7 January 2021

Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.

1 reference

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7 January 2021

STAT1-induced apoptosis is mediated by caspases 2, 3, and 7.

1 reference

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7 January 2021

Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.

1 reference

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7 January 2021

STAT1: a modulator of chemotherapy-induced apoptosis

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7 January 2021

Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Stat3 activation in acute lung injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Stat-3 is required for pulmonary homeostasis during hyperoxia

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Endothelial cells require STAT3 for protection against endotoxin-induced inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis

1 reference

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7 January 2021

STAT-3 activity in chemically-induced hepatocellular carcinoma

1 reference

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7 January 2021

Loss of Stat5a delays mammary cancer progression in a mouse model.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

STAT proteins as novel targets for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Retraction Note: TGFβ1 activates c-Jun and Erk1 via aVβ6 integrin

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a

1 reference

https://api.crossref.org/works/10.1038%2FNCPONC0195

7 January 2021

Identifiers

DOI

10.1038/NCPONC0195

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13 August 2017

1 reference