(Q36305967)

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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

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30 January 2020

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities (English)

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30 January 2020

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dopaminergic neuron

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Tatsunori Maekawa

1

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30 January 2020

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Sayuri Mori

2

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30 January 2020

Yui Sasaki

3

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30 January 2020

Takashi Miyajima

4

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30 January 2020

Sadahiro Azuma

5

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30 January 2020

Etsuro Ohta

6

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30 January 2020

Fumiya Obata

7

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30 January 2020

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25 April 2012

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30 January 2020

Molecular Neurodegeneration

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30 January 2020

7

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30 January 2020

15

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30 January 2020

describes a project that uses

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11 June 2022

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Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

1 reference

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30 September 2017

Diversity in the regulation of autophagy and mitophagy: lessons from Parkinson's disease.

1 reference

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30 September 2017

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

1 reference

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30 September 2017

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

1 reference

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30 September 2017

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Structural organization of the Golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

LRRK2 function on actin and microtubule dynamics in Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

A comparative study of Lrrk2 function in primary neuronal cultures

1 reference

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30 September 2017

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

LRRK2 in Parkinson's disease: function in cells and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

1 reference

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30 September 2017

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

1 reference

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30 September 2017

Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

LRRK2 regulates synaptic vesicle endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

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30 September 2017

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

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30 September 2017

Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein

1 reference

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30 September 2017

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

1 reference

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30 September 2017

Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death

1 reference

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30 September 2017

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

1 reference

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30 September 2017

The RIP kinases: crucial integrators of cellular stress

1 reference

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30 September 2017

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

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30 September 2017

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

Microtubule Assembly in the Absence of Added Nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

The MPTP-treated mouse as a model of parkinsonism: how good is it?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

30 September 2017

LRRK2: a problem lurking in vesicle trafficking?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467184

29 June 2018

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

1 reference

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29 June 2018

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1 reference

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29 June 2018

Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

1 reference

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21 January 2018

Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease

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21 January 2018

A rotarod test for evaluation of motor skill learning

1 reference

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21 January 2018

Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal dopamine in a pre-symptomatic stage model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-15

21 January 2018

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1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-15

21 January 2018

Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-15

21 January 2018

Fragmentation of the Golgi apparatus: an early apoptotic event independent of the cytoskeleton.

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-15

21 January 2018

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-7-15

21 January 2018

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

1 reference

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21 January 2018

Autosomal dominant familial Parkinson disease: older onset of age, and good response to levodopa therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534020

12 December 2020

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Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microtubules in the organization of the Golgi complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534020

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of MPTP on locomotor activity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22534020

12 December 2020

based on heuristic

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Identifiers

10.1186/1750-1326-7-15

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30 January 2020

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30 January 2020

PubMed publication ID

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30 January 2020

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