(Q36331266)

English

Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

tumor progression

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based on heuristic

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author name string

Ethan A Kohn

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Yu-an Yang

2

1 reference

Europe PubMed Central

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13 August 2017

Zhijun Du

3

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Europe PubMed Central

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13 August 2017

Yoshiko Nagano

4

1 reference

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13 August 2017

Catherine M H Van Schyndle

5

1 reference

Europe PubMed Central

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13 August 2017

Michelle A Herrmann

6

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13 August 2017

Madeleine Heldman

7

1 reference

Europe PubMed Central

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13 August 2017

Jin-Qiu Chen

8

1 reference

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13 August 2017

Christina H Stuelten

9

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Europe PubMed Central

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13 August 2017

Kathleen C Flanders

10

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13 August 2017

Lalage M Wakefield

11

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13 August 2017

language of work or name

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publication date

9 August 2012

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13 August 2017

Molecular Cancer Research

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13 August 2017

10

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Europe PubMed Central

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13 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1389-1399

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions

1 reference

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30 September 2017

GOBO: gene expression-based outcome for breast cancer online

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Transforming growth factor-beta in breast cancer: too much, too late

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

TGF-beta-induced epithelial to mesenchymal transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?

1 reference

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30 September 2017

TGFbeta in Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

The consensus coding sequences of human breast and colorectal cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

N-cadherin as an invasion promoter: a novel target for antitumor therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

30 September 2017

Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

22 September 2018

Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

22 September 2018

The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

22 September 2018

Down-regulation of activin, activin receptors, and Smads in high-grade breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

22 September 2018

Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3475765

22 September 2018

Identifiers

10.1158/1541-7786.MCR-12-0136-T

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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