(Q36350678)

13 August 2017

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title

Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review (English)

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13 August 2017

Erich Gebhart

1

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13 August 2017

publication date

1 December 2005

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Clinical and Translational Oncology

13 August 2017

published in

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13 August 2017

volume

7

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13 August 2017

issue

11

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13 August 2017

page(s)

477-485

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Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

MYCN gene amplification. Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

HER-2/neu oncogene amplification by fluorescence in situ hybridization in epithelial tumors of the ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

Amplified c-MYC sequences localized by fluorescence in-situ hybridization on double minute chromosomes in acute myeloid leukemias

21 January 2018

1 reference

12 December 2020

Cytogenetic evolution of mycn and mdm2 amplification in the neuroblastoma ls tumour and its cell line

1 reference

12 December 2020

C-myc amplification, double minutes and homogenous staining regions in a case of AML.

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma

1 reference

12 December 2020

Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas

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12 December 2020

Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis

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12 December 2020

Relational mapping of MYCN and DDXI in band 2p24 and analysis of amplicon arrays in double minute chromosomes and homogeneously staining regions by use of free chromatin FISH.

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12 December 2020

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines

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12 December 2020

Cytogenetic analysis of three variants of clival chordoma

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12 December 2020

MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene

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12 December 2020

The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes

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12 December 2020

Analysis of double minutes and double minute-like chromatin in human and murine tumor cells using antikinetochore antibodies

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12 December 2020

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells

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12 December 2020

Advances in the analysis of chromosome alterations in human lung carcinomas

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors

1 reference

12 December 2020

Extrachromosomal gene amplification in acute myeloid leukemia; Characterization by metaphase analysis, comparative genomic hybridization, and semi-quantitative PCR

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12 December 2020

Analysis of the replication mode of double minutes using the PCC technique combined with BrdUrd labeling

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12 December 2020

Have double minutes functioning centromeres?

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12 December 2020

Chromosomal localization of amplified N-myc in neuroblastoma cells using a biotinylated probe

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12 December 2020

Double minutes in the papillary thyroid cancer cell line PTC-1113A.

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12 December 2020

Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: two case reports and a review of literature

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12 December 2020

Chromosome alterations in human small cell lung cancer: frequent involvement of 5q

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12 December 2020

De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19.

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12 December 2020

Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei

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12 December 2020

Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.

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12 December 2020

A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification

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12 December 2020

Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.

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12 December 2020

Double minutes are frequently found in ovarian carcinomas.

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12 December 2020

Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome

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12 December 2020

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

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12 December 2020

Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas.

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12 December 2020

Alternative pathways of MYCN gene copy number increase in primary neuroblastoma tumors

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12 December 2020

Relationship between gene amplification and chromosomal deviations in malignant human gliomas

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12 December 2020

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma

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12 December 2020

Characterization of the C-MYC amplicon in a case of acute myeloid leukemia with double minute chromosomes

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12 December 2020

Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

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12 December 2020

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

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12 December 2020

MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasms

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12 December 2020

Cloning of a non-c-myc DNA fragment from the double minutes of a human colon carcinoid cell line

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12 December 2020

Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

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12 December 2020

Trisomy 4 and double minutes in acute myeloid leukemia: further evidence that double minutes can occur as the primary cytogenetic abnormality

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12 December 2020

MDM2 gene amplification correlates with ring chromosome in soft tissue tumors

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12 December 2020

Overview of monoclonal antibodies in cancer therapy: present and promise

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12 December 2020

A new approach of brain tumors: the cytogenetic study.

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12 December 2020

Chromosomal aberrations in breast cancer: a comparison between cytogenetics and comparative genomic hybridization

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12 December 2020

Incidence of double minutes, cytogenetic equivalents of gene amplification, in human carcinoma cells

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12 December 2020

Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines

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12 December 2020

Molecular cytogenetic analysis of a pleuropulmonary blastoma

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma

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12 December 2020

Oncogenes as novel targets for cancer therapy (part I): growth factors and protein tyrosine kinases

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12 December 2020

Patterns of BrdU incorporation in homogeneously staining regions and double minutes

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12 December 2020

Double minutes and c-MYC amplification in acute myelogenous leukemia: Are they prognostic factors?

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12 December 2020

When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

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12 December 2020

Presence of telomeric sequences on deleted chromosomes and their absence on double minutes in cell line HL-60.

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12 December 2020

Cytogenetic and molecular findings related to rhabdomyosarcoma. An analysis of seven cases

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12 December 2020

Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia

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12 December 2020

Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines

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12 December 2020

Oncogenic role of eIF-5A2 in the development of ovarian cancer

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12 December 2020

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

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12 December 2020

Double minute chromosomes in human leukemia

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12 December 2020

Targeting HER2 as a therapeutic strategy for breast cancer: a paradigmatic shift of drug development in oncology.

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12 December 2020

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

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12 December 2020

Chromosome abnormalities in human non-small cell lung cancer

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12 December 2020

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

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12 December 2020

Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: lipoma

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12 December 2020

HER-2/neu oncogene amplification in stage I and stage III ovarian papillary serous carcinoma

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12 December 2020

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

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12 December 2020

Cryptic ins(2;11) with clonal evolution showing amplification of 11q23-q25 either on hsr(11) or on dmin, in a patient with AML-M2.

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12 December 2020

Double minute chromosomes in a patient with myelodysplastic syndrome transforming into acute myeloid leukemia

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12 December 2020

Apparent lack of telomere sequences on double minute chromosomes

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12 December 2020

Cytogenetics and molecular genetics of lung cancer

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12 December 2020

Coamplification of simple repetitive DNA fingerprint fragments and the EGFR gene in human gliomas

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12 December 2020

Double minutes in human tumor cells

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma

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12 December 2020

[c-myc gene amplification and N-ras transforming gene in two cases of acute myelocytic leukemia with double minute chromosomes]

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12 December 2020

Nucleus extraction from single mounted tissue sections

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12 December 2020

Cytogenetics and DNA amplification in colorectal cancers

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12 December 2020

17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ

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12 December 2020

Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer

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12 December 2020

Molecular therapy of head and neck cancer.

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12 December 2020

Ultrastructural organization of double minute chromosomes and HSR regions in human colon carcinoma cells

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12 December 2020

Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

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12 December 2020

Molecularly targeted therapies for breast cancer

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors

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12 December 2020

Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome

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12 December 2020

MYC amplification in two further cases of acute myeloid leukemia with trisomy 4 and double minute chromosomes

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12 December 2020

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

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12 December 2020

Updates on cytogenetics and molecular genetics of bone and soft tissue tumors: Ewing sarcoma and peripheral primitive neuroectodermal tumors

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12 December 2020

Are double minutes chromosomes?

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12 December 2020

Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines

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12 December 2020

c-myc amplification in a preleukemia patient with trisomy 4 and double minutes: review of the unique coexistence of these two chromosome abnormalities in acute myelogenous leukemia

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12 December 2020

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies

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12 December 2020

Localization of amplified MYC gene sequences to double minute chromosomes in acute myelogenous leukemia

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12 December 2020

Clinical laboratory assays for HER-2/neu amplification and overexpression: quality assurance, standardization, and proficiency testing

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12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma

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12 December 2020

Co-existence of pseudo-Chediak-Higashi anomaly and double minutes containing C-MYC oncogene in three patients with AML M2

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12 December 2020

Rings and double minutes in a case with blastic phase of chronic myelocytic leukemia

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12 December 2020

Microdissection and microcloning of chromosomal alterations in human breast cancer

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12 December 2020

Oncogene amplification in human gliomas: a molecular cytogenetic analysis

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12 December 2020

Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia

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12 December 2020

Identification of the origin of double minutes in normal human cells by laser-based chromosome microdissection approach

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12 December 2020

Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft

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12 December 2020

Gene amplification and drug resistance

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12 December 2020

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases

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12 December 2020

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

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12 December 2020

Double minutes replicate once during S phase of the cell cycle

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12 December 2020

Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks

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12 December 2020

Chromosomes of human cancer cells

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12 December 2020

Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis

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12 December 2020

Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping

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12 December 2020

Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene

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12 December 2020

Identifiers

DOI

10.1007/BF02717000

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13 August 2017

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