(Q36354162)

English

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

S G Lebecque

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

P J Gearhart

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

1 December 1990

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

172

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1717-1727

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

DNA Methylation and Gene Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Clusters of point mutations are found exclusively around rearranged antibody variable genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Antibody diversity: somatic hypermutation of rearranged VH genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Patterns of somatic mutations in immunoglobulin variable genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Somatic evolution of variable region structures during an immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Transcriptional controlling elements in the immunoglobulin and T cell receptor loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

One role for DNA methylation in vertebrate cells is strand discrimination in mismatch repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

The role of somatic hypermutation in the generation of antibody diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Structural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Analysis of somatic mutations in kappa transgenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Somatic diversification of chicken immunoglobulin light chains by point mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Molecular basis of base substitution hotspots in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

30 September 2017

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Inequality in mutation rates of the two strands of DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

A better cell line for making hybridomas secreting specific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

29 June 2018

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

22 September 2018

The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

22 September 2018

Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2188766

22 September 2018

5' flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cruciform structures in supercoiled DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patterns of nucleotide substitution in pseudogenes and functional genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of clonal selection and somatic mutation in autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/2258702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.172.6.1717

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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