(Q36362388)

13 August 2017

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title

A PANorama of PAX genes in cancer and development (English)

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13 August 2017

Ewan J D Robson

1

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13 August 2017

Shu-Jie He

series ordinal

2

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13 August 2017

Michael R Eccles

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 January 2006

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13 August 2017

Nature Reviews Cancer

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13 August 2017

6

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13 August 2017

1

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13 August 2017

52-62

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https://scigraph.springernature.com/pub.10.1038/nrc1778

13 August 2017

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cites work

PAX2 suppresses apoptosis in renal collecting duct cells

1 reference

Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors

21 January 2018

1 reference

Pax5 expression in non-Hodgkin's lymphomas and acute leukemias

21 January 2018

1 reference

Pax genes and organogenesis.

21 January 2018

1 reference

Pax7 is required for the specification of myogenic satellite cells

31 March 2020

1 reference

Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Diabetes and pancreatic tumours in transgenic mice expressing Pa x 6.

31 March 2020

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Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

31 March 2020

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Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

31 March 2020

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Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity

31 March 2020

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Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells.

31 March 2020

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Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus

31 March 2020

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PAX6 suppresses growth of human glioblastoma cells.

31 March 2020

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Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member

31 March 2020

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Retinoblastoma protein acts as Pax 8 transcriptional coactivator.

31 March 2020

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Divergent functions of murine Pax3 and Pax7 in limb muscle development

31 March 2020

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A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch

31 March 2020

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A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors.

31 March 2020

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Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse.

31 March 2020

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Development of the inner ear in Splotch mutant mice.

31 March 2020

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PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse.

31 March 2020

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Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification.

31 March 2020

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Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal

31 March 2020

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Pax3 functions at a nodal point in melanocyte stem cell differentiation

31 March 2020

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PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells

31 March 2020

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Normal and rearranged PAX3 expression in human rhabdomyosarcoma

31 March 2020

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Expression of PAX3 in Ewing's sarcoma family of tumors

31 March 2020

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The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc

31 March 2020

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PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group

31 March 2020

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Mechanisms of sarcoma development

31 March 2020

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Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein

31 March 2020

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Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE).

31 March 2020

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Prognostic significance of molecular upstaging of paraffin-embedded sentinel lymph nodes in melanoma patients

31 March 2020

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Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR

31 March 2020

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Neural tube is partially dorsalized by overexpression of HrPax-37: the ascidian homologue of Pax-3 and Pax-7.

31 March 2020

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The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.

31 March 2020

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Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3.

31 March 2020

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Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice.

31 March 2020

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Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk

31 March 2020

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The role of Pax2 in mouse inner ear development

31 March 2020

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Expression of the PAX2 oncogene in human breast cancer and its role in progesterone-dependent mammary growth

31 March 2020

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Follicular cells of the thyroid gland require Pax8 gene function

31 March 2020

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Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations

31 March 2020

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Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

31 March 2020

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Nephric lineage specification by Pax2 and Pax8

31 March 2020

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Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear.

31 March 2020

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Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.

31 March 2020

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Ureteric Bud Apoptosis and Renal Hypoplasia in Transgenic PAX2-Bax Fetal Mice Mimics the Renal-Coloboma Syndrome

31 March 2020

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The renal papilla is a niche for adult kidney stem cells

31 March 2020

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Loss of p53 function through PAX-mediated transcriptional repression.

31 March 2020

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PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis

31 March 2020

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Aberrant expression of Pax-2 mRNA in renal cell carcinoma tissue and parenchyma of the affected kidney

31 March 2020

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Pax-2 expression in adult renal tumors.

31 March 2020

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Gene expression patterns in ovarian carcinomas

31 March 2020

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Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor

31 March 2020

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Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPAR(gamma) fusion oncogene.

31 March 2020

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Cytoplasmic localization of the paired box gene, Pax-8, is found in pediatric thyroid cancer and may be associated with a greater risk of recurrence

31 March 2020

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Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines

31 March 2020

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PAX8 and peroxisome proliferator-activated receptor gamma 1 gene expression status in benign and malignant thyroid tissues.

31 March 2020

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Underexpression of peroxisome proliferator-activated receptor (PPAR)gamma in PAX8/PPARgamma-negative thyroid tumours

31 March 2020

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Involvement of the PAX8/peroxisome proliferator-activated receptor gamma rearrangement in follicular thyroid tumors.

31 March 2020

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PAX8-PPARgamma rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses

31 March 2020

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RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

31 March 2020

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Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas.

31 March 2020

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PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]

31 March 2020

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The PAX8/PPARgamma fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARgamma inhibition

31 March 2020

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The PAX8/PPAR gamma fusion oncogene as a potential therapeutic target in follicular thyroid carcinoma

31 March 2020

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Transcriptional control of early B cell development

31 March 2020

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

31 March 2020

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EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells

31 March 2020

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Stat proteins and oncogenesis

31 March 2020

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The STATs of cancer--new molecular targets come of age

31 March 2020

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PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements

31 March 2020

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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma

31 March 2020

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The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S-type cell line.

31 March 2020

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Deregulated expression of PAX5 in medulloblastoma

31 March 2020

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Expression of dominant negative form of PAX4 in human insulinoma

31 March 2020

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Getting your Pax straight: Pax proteins in development and disease

31 March 2020

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Pax genes and eye organogenesis

31 March 2020

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Pax6; a pleiotropic player in development.

31 March 2020

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Mouse small eye results from mutations in a paired-like homeobox-containing gene

31 March 2020

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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

31 March 2020

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Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type

31 March 2020

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31 March 2020

Why cavefish are blind

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Potential for neural regeneration after neurotoxic injury in the adult mammalian retina

31 March 2020

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PAX6 in sensory development

31 March 2020

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Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

31 March 2020

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Lens induction by Pax-6 in Xenopus laevis.

31 March 2020

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De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines

31 March 2020

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DNA methylation differences associated with tumor tissues identified by genome scanning analysis

31 March 2020

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PAX6 methylation and ectopic expression in human tumor cells

31 March 2020

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Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

31 March 2020

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Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

31 March 2020

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Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome

31 March 2020

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Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.

31 March 2020

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Novel mutation of the initiation codon of PAX9 causes oligodontia

31 March 2020

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A missense mutation in PAX9 in a family with distinct phenotype of oligodontia

31 March 2020

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Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia

31 March 2020

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Mutation of PAX9 is associated with oligodontia

31 March 2020

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Regulation of Pax5 in Lipopolysaccharide-Activated B Cells

31 March 2020

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

31 March 2020

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Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

31 March 2020

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The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

31 March 2020

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An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

31 March 2020

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Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals.

31 March 2020

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Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1778

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13 August 2017

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