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Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis.
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Europe PubMed Central
PubMed publication ID
16407878
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
review article
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title
Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
(English)
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Europe PubMed Central
PubMed publication ID
16407878
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
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pathophysiology
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Markus J Seibel
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3
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Europe PubMed Central
PubMed publication ID
16407878
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retrieved
15 January 2020
Colin Dunstan
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4
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Europe PubMed Central
PubMed publication ID
16407878
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15 January 2020
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Julie M Blair
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1
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Europe PubMed Central
PubMed publication ID
16407878
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
Hong Zhou
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2
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Europe PubMed Central
PubMed publication ID
16407878
reference URL
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15 January 2020
publication date
1 January 2006
1 reference
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Europe PubMed Central
PubMed publication ID
16407878
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
published in
Nature Clinical Practice Oncology
1 reference
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Europe PubMed Central
PubMed publication ID
16407878
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
volume
3
1 reference
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Europe PubMed Central
PubMed publication ID
16407878
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
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15 January 2020
issue
1
1 reference
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Europe PubMed Central
PubMed publication ID
16407878
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
41-49
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Europe PubMed Central
PubMed publication ID
16407878
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
cites work
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Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
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Crossref
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Metastasis to bone: causes, consequences and therapeutic opportunities
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Histological, immunophenotypic and histomorphometric characterization of prostate cancer bone metastases
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7 January 2021
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Clinical use of markers of bone turnover in metastatic bone disease.
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
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Bone metastases: pathophysiology and management policy
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
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inferred from DOI database lookup
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
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7 January 2021
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
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inferred from DOI database lookup
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
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7 January 2021
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inferred from DOI database lookup
Osteoprotegerin deficiency and juvenile Paget's disease.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
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Crossref
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes
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https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Opg, RANKl, and RANK in cancer metastasis: expression and regulation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: analysis by real-time quantitative PCR
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin and rank ligand expression in prostate cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin and osteopontin serum values in postmenopausal advanced breast cancer patients treated with anastrozole
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serum osteoprotegerin and receptor activator of nuclear factor-kappa B ligand as indicators of disturbed osteoclastogenesis in patients with prostate cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RANK ligand and osteoprotegerin in myeloma bone disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple myeloma biology: lessons from the 5TMM models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RANK-Fc: a therapeutic antagonist for RANK-L in myeloma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel osteoblast-derived C-type lectin that inhibits osteoclast formation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Receptor activator of NF-kappaB ligand (RANKL) is expressed in chondroblastoma: possible involvement in osteoclastic giant cell recruitment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of parathyroid hormone-related protein (PTHrP), osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin (OPG) in ameloblastomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of osteoclast differentiation signals by stromal elements of giant cell tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunocytochemistry reveals RANKL expression of myeloma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNCPONC0381
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NCPONC0381
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16407878
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed publication ID
16407878
1 reference
stated in
Europe PubMed Central
PubMed publication ID
16407878
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16407878%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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