(Q36369916)

13 August 2017

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title

Titin: physiological function and role in cardiomyopathy and failure (English)

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13 August 2017

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Henk Granzier

1

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13 August 2017

Yiming Wu

series ordinal

2

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13 August 2017

Labeit Siegfried

series ordinal

3

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13 August 2017

Martin LeWinter

series ordinal

4

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13 August 2017

language of work or name

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1 September 2005

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13 August 2017

published in

Heart Failure Reviews

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13 August 2017

volume

10

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13 August 2017

issue

3

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13 August 2017

page(s)

211-223

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https://scigraph.springernature.com/pub.10.1007/s10741-005-5251-7

13 August 2017

exact match

0 references

cites work

Familial dilated cardiomyopathy locus maps to chromosome 2q31.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10741-005-5251-7

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

21 January 2018

1 reference

12 December 2020

Does titin regulate the length of muscle thick filaments?

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12 December 2020

Reverse engineering of the giant muscle protein titin

1 reference

12 December 2020

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity

1 reference

12 December 2020

Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases

1 reference

12 December 2020

Chromosomal localization of the mouse titin gene and its relation to "muscular dystrophy with myositis" and nebulin genes on chromosome 2.

1 reference

12 December 2020

Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin

1 reference

12 December 2020

Order of six loci at 2q24-q31 and orientation of the HOXD locus.

1 reference

12 December 2020

Titin, myosin light chains and C-protein in the developing and failing human heart

1 reference

12 December 2020

Structural and functional studies of titin’s fn3 modules reveal conserved surface patterns and binding to myosin S1 - a possible role in the frank-starling mechanism of the heart

1 reference

12 December 2020

Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments

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12 December 2020

Molecular and cellular mechanisms of myocardial failure

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12 December 2020

Titin/connectin and nebulin: giant protein rulers of muscle structure and function

1 reference

12 December 2020

A spring tale: new facts on titin elasticity

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12 December 2020

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

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12 December 2020

Titin isoform expression in normal and hypertensive myocardium

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12 December 2020

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle

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12 December 2020

Molecular mechanics of cardiac titin's PEVK and N2B spring elements.

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12 December 2020

Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness

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12 December 2020

Cycling cross-bridges increase myocardial stiffness at submaximal levels of Ca2+ activation.

1 reference

12 December 2020

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

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12 December 2020

Cardiac ankyrin repeat protein is preferentially induced in atrophic myofibers of congenital myopathy and spinal muscular atrophy

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12 December 2020

Location of the C-terminus of titin at the Z-line region in the sarcomere

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12 December 2020

The maximum length for contraction in vertebrate straiated muscle

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12 December 2020

Elastic properties of the titin filament in the Z-line region of vertebrate striated muscle

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12 December 2020

Role of the giant elastic protein titin in the Frank-Starling mechanism of the heart

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12 December 2020

Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction.

1 reference

12 December 2020

Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies

1 reference

12 December 2020

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

1 reference

12 December 2020

A regular pattern of two types of 100-residue motif in the sequence of titin

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12 December 2020

Molecular dissection of N2B cardiac titin's extensibility

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12 December 2020

Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation

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12 December 2020

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

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12 December 2020

Alterations in the determinants of diastolic suction during pacing tachycardia

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12 December 2020

Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes

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12 December 2020

The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line

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12 December 2020

Skeletal muscle gene expression in space-flown rats

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12 December 2020

Cardiomyocyte Stiffness in Diastolic Heart Failure

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12 December 2020

Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system

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12 December 2020

Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes

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12 December 2020

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination

1 reference

12 December 2020

Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I

1 reference

12 December 2020

Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart

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12 December 2020

Direct evidence for connecting C filaments in flight muscle of honey bee

1 reference

12 December 2020

Dynamics of viscoelastic properties of rat cardiac sarcomeres during the diastolic interval: involvement of Ca2+.

1 reference

12 December 2020

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

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12 December 2020

The Muscle Ankyrin Repeat Proteins: CARP, ankrd2/Arpp and DARP as a Family of Titin Filament-based Stress Response Molecules

1 reference

12 December 2020

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

1 reference

12 December 2020

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

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12 December 2020

Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin

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12 December 2020

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

1 reference

12 December 2020

The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity

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12 December 2020

Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins

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12 December 2020

Titins: giant proteins in charge of muscle ultrastructure and elasticity

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12 December 2020

The muscular dystrophy with myositis (mdm) mouse mutation disrupts a skeletal muscle-specific domain of titin

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12 December 2020

Calcium-dependent molecular spring elements in the giant protein titin

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12 December 2020

A physiological role for titin and nebulin in skeletal muscle

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12 December 2020

Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes

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12 December 2020

Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals

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12 December 2020

Long term survivors of childhood leukemia

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12 December 2020

Identification of ubiquitin ligases required for skeletal muscle atrophy

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12 December 2020

Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle.

1 reference

12 December 2020

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

1 reference

12 December 2020

I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure

1 reference

12 December 2020

Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis

1 reference

12 December 2020

Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation

1 reference

12 December 2020

Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.

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12 December 2020

Structural basis for activation of the titin kinase domain during myofibrillogenesis

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12 December 2020

Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring.

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12 December 2020

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy

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12 December 2020

Titin develops restoring force in rat cardiac myocytes

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12 December 2020

Folding-unfolding transitions in single titin molecules characterized with laser tweezers.

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12 December 2020

Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3.

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12 December 2020

Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium

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12 December 2020

Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness

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12 December 2020

Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein

1 reference

12 December 2020

Extensible and less-extensible domains of connectin filaments in stretched vertebrate skeletal muscle sarcomeres as detected by immunofluorescence and immunoelectron microscopy using monoclonal antibodies

1 reference

12 December 2020

Tibial muscular dystrophy--from clinical description to linkage on chromosome 2q31.

1 reference

12 December 2020

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

1 reference

12 December 2020

Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

1 reference

12 December 2020

Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently

1 reference

12 December 2020

Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils

1 reference

12 December 2020

Length modulation of active force in rat cardiac myocytes: is titin the sensor?

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12 December 2020

Titin isoform switch in ischemic human heart disease.

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12 December 2020

Titin mutations as the molecular basis for dilated cardiomyopathy

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12 December 2020

The kinase domain of titin controls muscle gene expression and protein turnover

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12 December 2020

Mechanical properties of titin isoforms

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12 December 2020

Histology of highly-stretched beef muscle. IV. Evidence for movement of gap filaments through the Z-line, using the N2-line and M-line as markers

1 reference

12 December 2020

Length dependence of tension generation in rat skinned cardiac muscle: role of titin in the Frank-Starling mechanism of the heart

1 reference

12 December 2020

Titin-actin interaction in mouse myocardium: passive tension modulation and its regulation by calcium/S100A1

1 reference

12 December 2020

Altered expression of titin and contractile proteins in failing human myocardium

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12 December 2020

The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin

1 reference

12 December 2020

Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs.

1 reference

12 December 2020

Association of the chaperone alphaB-crystallin with titin in heart muscle.

1 reference

12 December 2020

Titin determines the Frank-Starling relation in early diastole

1 reference

12 December 2020

Titin and nebulin: protein rulers in muscle?

1 reference

12 December 2020

Differential expression of cardiac titin isoforms and modulation of cellular stiffness

1 reference

12 December 2020

10.1007/S10741-005-5251-7

Identifiers

DOI

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13 August 2017

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