(Q36371091)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

0 references

1 reference

chronic lymphocytic leukemia

1 reference

5

1 reference

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12 November 2019

Steven Allen

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Manlio Ferrarini

10

1 reference

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12 November 2019

author name string

Carmela Gurrieri

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Peter McGuire

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Hong Zan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Xiao-Jie Yan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Emilia Albesiano

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Vincent Vinciguerra

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Kanti R Rai

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Paolo Casali

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Nicholas Chiorazzi

12

1 reference

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12 November 2019

language of work or name

English

0 references

publication date

1 September 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

12 November 2019

published in

1 reference

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12 November 2019

volume

196

1 reference

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12 November 2019

issue

5

1 reference

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12 November 2019

page(s)

629-639

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

12 November 2019

cites work

1 reference

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

30 September 2017

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

30 September 2017

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Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line

30 September 2017

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

30 September 2017

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The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

30 September 2017

1 reference

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Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells.

30 September 2017

1 reference

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CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

30 September 2017

1 reference

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BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia

30 September 2017

1 reference

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

30 September 2017

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Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas

30 September 2017

1 reference

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Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells

30 September 2017

1 reference

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Germinal centers without T cells

30 September 2017

1 reference

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Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

30 September 2017

1 reference

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Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

30 September 2017

1 reference

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

30 September 2017

1 reference

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Clonal evolution of B cells in transformation from low- to high-grade lymphoma

30 September 2017

1 reference

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Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation

30 September 2017

1 reference

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An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia

30 September 2017

1 reference

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

30 September 2017

1 reference

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

30 September 2017

1 reference

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Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.

30 September 2017

1 reference

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Induction of somatic mutation in a human B cell line in vitro

30 September 2017

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VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.

30 September 2017

1 reference

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VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

30 September 2017

1 reference

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Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.

30 September 2017

1 reference

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IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

30 September 2017

1 reference

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B-cell lineages exist in the mouse

30 September 2017

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Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections

30 September 2017

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30 September 2017

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The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

30 September 2017

1 reference

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Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors

30 September 2017

1 reference

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Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia

30 September 2017

1 reference

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Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells

30 September 2017

1 reference

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

30 September 2017

1 reference

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B-1 cellular origin and VH segment structure of IgG, IgA, and IgM anti-DNA autoantibodies in patients with systemic lupus erythematosus

30 September 2017

1 reference

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Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

30 September 2017

1 reference

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Intraclonal generation of antibody mutants in germinal centres

30 September 2017

1 reference

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

30 September 2017

1 reference

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Developmental origins, specificities and immunoglobulin gene biases of murine Ly-1 B cells

30 September 2017

1 reference

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Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

30 September 2017

1 reference

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Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia

30 September 2017

1 reference

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T cell helper defect in patients with chronic lymphocytic leukemia

30 September 2017

1 reference

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Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes

30 September 2017

1 reference

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Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis

30 September 2017

1 reference

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

28 June 2018

1 reference

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Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia

28 June 2018

1 reference

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Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia

28 June 2018

1 reference

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Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia

28 June 2018

1 reference

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Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.

28 June 2018

1 reference

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Maturation of the immune response in germinal centers

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

Biased usage of variable and constant-region Ig genes by IgG+, CD5+ human leukemic B cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

IgG-secreting lymphoplasmacytoid leukaemia: a B-cell disorder with extensively mutated VH genes undergoing Ig isotype-switching frequently associated with trisomy 12.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

Adhesion to bone marrow stroma inhibits apoptosis of chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching

21 January 2018

1 reference

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Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194006

B Cell Receptor Engagement and T Cell Contact Induce bcl-6 Somatic Hypermutation in Human B Cells: Identity with Ig Hypermutation

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

The role of clonal selection and somatic mutation in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

B cells of chronic lymphatic leukemia express V genes in unmutated form

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

21 January 2018

The Ly-1 B cell lineage

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20011693

B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro

21 January 2018

1 reference

12 December 2020

Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification

1 reference

12 December 2020

CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis

1 reference

12 December 2020

Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells

1 reference

12 December 2020

Nonimmunoglobulin gene hypermutation in germinal center B cells

1 reference

12 December 2020

Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD

1 reference

12 December 2020

Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia

1 reference

12 December 2020

Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20011693

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

12208878

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12208878%20AND%20SRC:MED&resulttype=core&format=json