(Q36399980)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

0 references

1 reference

5

1 reference

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16 February 2020

author name string

Kaidong Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Brian M Shafer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Matthew D Demars

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Harry A Stern

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

language of work or name

English

0 references

publication date

2 November 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

Journal of the American Chemical Society

16 February 2020

published in

1 reference

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16 February 2020

volume

134

1 reference

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16 February 2020

issue

45

1 reference

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16 February 2020

page(s)

18695-18704

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.

16 February 2020

cites work

1 reference

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Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.

30 September 2017

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Innate and Guided C–H Functionalization Logic

30 September 2017

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30 September 2017

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If C-H bonds could talk: selective C-H bond oxidation

30 September 2017

1 reference

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Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes

30 September 2017

1 reference

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Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

30 September 2017

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Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

30 September 2017

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The global portfolio of new antimalarial medicines under development.

30 September 2017

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Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity

30 September 2017

1 reference

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Chemo-enzymatic fluorination of unactivated organic compounds

30 September 2017

1 reference

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Biologically inspired oxidation catalysis

30 September 2017

1 reference

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Qinghaosu (Artemisinin): The Price of Success

30 September 2017

1 reference

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A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis

30 September 2017

1 reference

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Cytochromes P450 as versatile biocatalysts

30 September 2017

1 reference

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Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s

30 September 2017

1 reference

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A medicinal chemistry perspective on artemisinin and related endoperoxides

30 September 2017

1 reference

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Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam

30 September 2017

1 reference

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Pivotal role of water in the mechanism of P450BM-3

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Pharmacokinetics of artemisinin-type compounds

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Structure of a cytochrome P450-redox partner electron-transfer complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

30 September 2017

1 reference

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The role of Thr268 in oxygen activation of cytochrome P450BM-3

30 September 2017

1 reference

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A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

30 September 2017

1 reference

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Controlling site selectivity in palladium-catalyzed C-H bond functionalization

28 June 2018

1 reference

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Biotransformation of artemisinin using cell suspension cultures of Catharanthus roseus (L.) G.Don and Lavandula officinalis L.

21 September 2018

1 reference

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Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme.

21 September 2018

1 reference

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Total synthesis of eudesmane terpenes by site-selective C-H oxidations.

21 September 2018

1 reference

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Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

21 September 2018

1 reference

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Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

21 September 2018

1 reference

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Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

21 September 2018

1 reference

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Artemisone--a highly active antimalarial drug of the artemisinin class

21 September 2018

1 reference

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A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273.

21 September 2018

1 reference

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Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger.

21 September 2018

1 reference

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Altering the regioselectivity of cytochrome P450 CYP102A3 of Bacillus subtilis by using a new versatile assay system

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Oxaziridine-mediated catalytic hydroxylation of unactivated 3 degrees C-H bonds using hydrogen peroxide

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Palladium-catalyzed oxygenation of unactivated sp3 C-H bonds

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

A highly selective catalytic method for the oxidative functionalization of C-H bonds

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Selective functionalization of amino acids in water: a synthetic method via catalytic C-H bond activation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Further improvement of phosphite dehydrogenase thermostability by saturation mutagenesis

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498520

Chemospecific chromium[VI] catalyzed oxidation of C-H bonds at -40 degrees C1

21 October 2018

1 reference

12 December 2020

A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation†

1 reference

12 December 2020

Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues

1 reference

12 December 2020

Stereospecific CH Oxidation with H2O2Catalyzed by a Chemically Robust Site-Isolated Iron Catalyst

1 reference

12 December 2020

Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst

1 reference

12 December 2020

Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes

1 reference

12 December 2020

A regioselective biocatalyst for alkane activation under mild conditions

1 reference

12 December 2020

Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4

1 reference

12 December 2020

Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium

1 reference

12 December 2020

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA3073462

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference