(Q36402221)

14 August 2017

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title

Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease (English)

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14 August 2017

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Simard AR

1

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14 August 2017

Rivest S

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 April 2006

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14 August 2017

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14 August 2017

11

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14 August 2017

327-335

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14 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.mp.4001809

14 August 2017

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21 January 2018

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Interleukin-1β protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo

21 January 2018

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TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.

21 January 2018

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

21 January 2018

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Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras

21 January 2018

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Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice

21 January 2018

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Migration of exogenous immature hematopoietic cells into adult mouse brain parenchyma under GFP-expressing bone marrow chimera.

21 January 2018

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From marrow to brain: expression of neuronal phenotypes in adult mice.

21 January 2018

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Differentiation of transplanted bone marrow cells in the adult mouse brain

21 January 2018

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Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

21 January 2018

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Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.

21 January 2018

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Failure of bone marrow cells to transdifferentiate into neural cells in vivo.

21 January 2018

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Neuroectodermal and microglial differentiation of bone marrow cells in the mouse spinal cord and sensory ganglia.

21 January 2018

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Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

21 January 2018

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Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

21 January 2018

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Hematopoietic cells maintain hematopoietic fates upon entering the brain.

21 January 2018

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Responses of microglia and neural progenitors to mechanical brain injury.

21 January 2018

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Tumor necrosis factor reduces brain tumor growth by enhancing macrophage recruitment and microcyst formation.

21 January 2018

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Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Inflammation is detrimental for neurogenesis in adult brain

21 January 2018

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The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.

21 January 2018

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Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

21 January 2018

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Molecular approaches to spinal cord repair

21 January 2018

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Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.

21 January 2018

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

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Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody

21 January 2018

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Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

21 January 2018

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MHC class II-positive microglia in human brain: association with Alzheimer lesions

21 January 2018

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Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms.

21 January 2018

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The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein

21 January 2018

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Microglia in health and disease

21 January 2018

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Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

21 January 2018

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Activation of microglial cells by beta-amyloid protein and interferon-gamma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Alzheimer's disease and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

beta-Amyloid peptides induce degeneration of cultured rat microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Decline of immune responsiveness: a pathogenetic factor in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Glucocorticoids play a fundamental role in protecting the brain during innate immune response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Interleukin-1beta promotes repair of the CNS.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Relationship between beta-AP peptide aggregation and microglial activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Microglia and neuroprotection: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001809

7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001809

1 reference

Dimensions Publication ID

14 August 2017

0 references

1 reference