(Q36414506)

14 August 2017

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title

Evolving knowledge and therapy of inflammatory bowel disease (English)

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inflammatory bowel diseases

14 August 2017

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inflammation

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author name string

Joshua R Korzenik

series ordinal

1

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PubMed ID

16518373

14 August 2017

Daniel K Podolsky

series ordinal

2

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PubMed ID

16518373

14 August 2017

language of work or name

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1 March 2006

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Nature Reviews Drug Discovery

14 August 2017

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14 August 2017

5

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14 August 2017

197-209

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14 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrd1986

14 August 2017

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cites work

Inflammatory Bowel Disease

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21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Genetic variation in DLG5 is associated with inflammatory bowel disease

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A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)

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CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

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Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

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21 January 2018

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Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

21 January 2018

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

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Treatment of severe Crohn's disease with anti-CD4 monoclonal antibody.

21 January 2018

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CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study

21 January 2018

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Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis.

21 January 2018

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Anti-interleukin-12 antibody for active Crohn's disease

21 January 2018

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Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

21 January 2018

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Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA.

21 January 2018

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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.

21 January 2018

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Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease

21 January 2018

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Allergy, parasites, and the hygiene hypothesis

21 January 2018

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Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift

21 January 2018

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Liver regeneration, growth factors, and amphiregulin

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Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice.

21 January 2018

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21 January 2018

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A randomized, double-blind, placebo-controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, in patients with corticosteroid-dependent Crohn's disease

21 January 2018

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Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial

21 January 2018

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Intravenous CDP870, a PEGylated Fab' fragment of a humanized antitumour necrosis factor antibody, in patients with moderate-to-severe Crohn's disease: an exploratory study

21 January 2018

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Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial

21 January 2018

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Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

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Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

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Microencapsulation of Tumor Necrosis Factor Oligomers: A New Approach to Proinflammatory Cytokine Inhibition

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Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

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Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease

21 January 2018

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In vitro effects of oxpentifylline on inflammatory cytokine release in patients with inflammatory bowel disease

21 January 2018

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Rational design and development of RDP58.

21 January 2018

1 reference

RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

21 January 2018

1 reference

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

21 January 2018

1 reference

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

21 January 2018

1 reference

Peroxisome proliferator-activated receptor γ activators inhibit interleukin-12 production in murine dendritic cells

21 January 2018

1 reference

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

21 January 2018

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Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group

21 January 2018

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Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group

21 January 2018

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Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group

21 January 2018

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Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease

21 January 2018

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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

21 January 2018

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Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model

21 January 2018

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Transfection of IL-10 expression vectors into endothelial cultures attenuates alpha4beta7-dependent lymphocyte adhesion mediated by MAdCAM-1

21 January 2018

1 reference

Should adults be screened for celiac disease? What are the benefits and harms of screening?

21 January 2018

1 reference

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease.

21 January 2018

1 reference

Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease

21 January 2018

1 reference

A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis

21 January 2018

1 reference

Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody

21 January 2018

1 reference

Natalizumab for active Crohn's disease

21 January 2018

1 reference

A controlled trial of natalizumab for relapsing multiple sclerosis.

21 January 2018

1 reference

Natalizumab Induction and Maintenance Therapy for Crohn's Disease

21 January 2018

1 reference

Progressive multifocal leukoencephalopathy and natalizumab--unforeseen consequences.

21 January 2018

1 reference

Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease

21 January 2018

1 reference

Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis

21 January 2018

1 reference

Progressive multifocal leukoencephalopathy in a patient treated with natalizumab

21 January 2018

1 reference

JC virus DNA is present in the mucosa of the human colon and in colorectal cancers.

21 January 2018

1 reference

Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

21 January 2018

1 reference

Extracorporeal photochemotherapy in patients with steroid-dependent Crohn's disease: a prospective pilot study

21 January 2018

1 reference

Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study

21 January 2018

1 reference

Selective granulocyte and monocyte adsorptive apheresis as a first-line treatment for steroid naïve patients with active ulcerative colitis: a prospective uncontrolled study

21 January 2018

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Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis

21 January 2018

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Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis

21 January 2018

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A novel human fibroblast growth factor treats experimental intestinal inflammation

21 January 2018

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Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease

21 January 2018

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Association of glycogen storage disease 1b and Crohn disease: results of a North American survey

21 January 2018

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An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease

21 January 2018

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Sargramostim for active Crohn's disease

21 January 2018

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Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis.

21 January 2018

1 reference

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

21 January 2018

1 reference

Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli.

21 January 2018

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Modulation of human dendritic cell phenotype and function by probiotic bacteria

21 January 2018

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Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial

21 January 2018

1 reference

Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent-invasive E. coli strains isolated from patients with Crohn's disease.

21 January 2018

1 reference

Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling

21 January 2018

1 reference

Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial

21 January 2018

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Lactobacillus GG in inducing and maintaining remission of Crohn's disease

21 January 2018

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Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG.

21 January 2018

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Saccharomyces boulardii in maintenance treatment of Crohn's disease

21 January 2018

1 reference

A pilot trial of Saccharomyces boulardii in ulcerative colitis

21 January 2018

1 reference

Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat.

21 January 2018

1 reference

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

21 January 2018

1 reference

Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease

21 January 2018

1 reference

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

31 March 2020

1 reference

T(H)-17: a giant step from T(H)1 and T(H)2

31 March 2020

1 reference

Course of Crohn's disease after allogeneic marrow transplantation

31 March 2020

1 reference

A pilot study of centrifugal leukocyte apheresis for corticosteroid-resistant active ulcerative colitis

31 March 2020

1 reference

Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind, placebo-controlled, dose-escalation trial

31 March 2020

1 reference

A preliminary study of growth hormone therapy for Crohn's disease

31 March 2020

1 reference

Perioperative treatment with human growth hormone down-regulates apoptosis and increases superoxide production in PMN from patients undergoing infrarenal abdominal aortic aneurysm repair

31 March 2020

1 reference

Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor

31 March 2020

1 reference

A Polymorphism of the Bactericidal/Permeability Increasing Protein (BPI) Gene Is Associated With Crohn??s Disease

31 March 2020

1 reference

New technique of leukocytapheresis by the use of nonwoven polyester fiber filter for inflammatory bowel disease

31 March 2020

1 reference

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7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1986

1 reference

14 August 2017

1 reference

PubMed ID

16518373