(Q36414620)

English

Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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pulmonary fibrosis

1 reference

based on heuristic

inferred from title

author name string

Rishi B Patel

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Sainath R Kotha

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Shariq I Sherwani

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Sean M Sliman

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Travis O Gurney

5

1 reference

Europe PubMed Central

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14 August 2017

Brooke Loar

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Susan O'Connor Butler

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Andrew J Morris

8

1 reference

Europe PubMed Central

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14 August 2017

Clay B Marsh

9

1 reference

Europe PubMed Central

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14 August 2017

Narasimham L Parinandi

10

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Europe PubMed Central

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14 August 2017

language of work or name

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publication date

3 December 2010

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Europe PubMed Central

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14 August 2017

International Journal of Toxicology

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Europe PubMed Central

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14 August 2017

30

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Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

69-90

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Bleomycin and its role in inducing apoptosis and senescence in lung cells - modulating effects of caveolin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Exposures and idiopathic lung disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Pulmonary fibrosis: pathogenesis, etiology and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Disruption of iron homeostasis and lung disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Caveolae and caveolins in the respiratory system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Protein kinase inhibitors in the treatment of pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Two pathways for lysophosphatidic acid production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Oxidant-antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Murine models of pulmonary fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Pulmonary hypertension in patients with interstitial lung diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Oxidative stress and redox regulation of phospholipase D in myocardial disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Idiopathic interstitial pneumonias: Primum movens: epithelial, endothelial or whatever.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Metals, toxicity and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Mechanisms of lysophosphatidic acid production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Phospholipase D activation in endothelial cells is redox sensitive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Regulation of phospholipase D by phosphorylation-dependent mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Regulation of phospholipase D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Reactive oxygen species signaling through regulation of protein tyrosine phosphorylation in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Phosphatidate phosphohydrolase and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Enzymology of mammalian phospholipases D: in vitro studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Phospholipid signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Mechanisms of bleomycin-induced lung damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

30 September 2017

Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

28 June 2018

New developments in phospholipase D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

28 June 2018

Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

28 June 2018

Mitochondrial DNA damage by bleomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

28 June 2018

Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Role of lipid-derived free radical in bleomycin-induced lung injury in mice: availability for ESR spin trap method with organic phase extraction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3503147

21 September 2018

Pulmonary hypertension in interstitial lung disease

1 reference

https://api.crossref.org/works/10.1177%2F1091581810388850

21 January 2018

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of liposomal alpha-tocopherol against bleomycin-induced lung injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pulmonary hypertension in chronic respiratory and cardiac diseases]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of halopemide for phospholipase D2 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol alleviates bleomycin-induced lung injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21131602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1177/1091581810388850

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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