(Q36415326)

14 August 2017

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title

Target selectivity in mRNA silencing (English)

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14 August 2017

Aronin N

1

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14 August 2017

publication date

1 March 2006

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14 August 2017

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14 August 2017

volume

13

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14 August 2017

issue

6

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14 August 2017

page(s)

509-516

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302726

14 August 2017

exact match

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cites work

Targeted mRNA degradation by double-stranded RNA in vitro

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Perspective: machines for RNAi

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Phylogenetic shadowing and computational identification of human microRNA genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

RNAi in human cells: basic structural and functional features of small interfering RNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Crystal structure of Argonaute and its implications for RISC slicer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Purified Argonaute2 and an siRNA form recombinant human RISC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

ATP requirements and small interfering RNA structure in the RNA interference pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Specificity of microRNA target selection in translational repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Kinetic analysis of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Argonaute2 is the catalytic engine of mammalian RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

A protein sensor for siRNA asymmetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Allele-specific silencing of dominant disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

siRNA relieves chronic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

siRNA function in RNAi: a chemical modification analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302726

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

12 December 2020

Different delivery methods-different expression profiles

1 reference

12 December 2020

Target accessibility dictates the potency of human RISC

1 reference

12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

12 December 2020

Lack of interferon response in animals to naked siRNAs

1 reference

12 December 2020

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

12 December 2020

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

1 reference

12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

1 reference

12 December 2020

Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection

1 reference

12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.GT.3302726

1 reference

14 August 2017

1 reference