(Q36453405)

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The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress.

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4 March 2020

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress (English)

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4 March 2020

Orthoebolavirus zairense

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Kristen A Johnson

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4 March 2020

Robert V. Stahelin

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4 March 2020

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Geoffrey J F Taghon

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4 March 2020

Jordan L Scott

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12 January 2016

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4 March 2020

Scientific Reports

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4 March 2020

6

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4 March 2020

1

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19125

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4 March 2020

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Creative Commons Attribution 4.0 International

12 January 2016

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describes a project that uses

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11 June 2022

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https://scigraph.springernature.com/pub.10.1038/srep19125

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Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus

1 reference

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30 September 2017

ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress

1 reference

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Polyphosphoinositide binding domains: Key to inositol lipid biology.

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Phospholipid synthesis and transport in mammalian cells

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Conformational plasticity of the Ebola virus matrix protein

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Roles played by acidic lipids in HIV-1 Gag membrane binding

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Interaction of Mason-Pfizer monkey virus matrix protein with plasma membrane

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Role of phosphatidylserine receptors in enveloped virus infection

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Could the Ebola virus matrix protein VP40 be a drug target?

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Effect of multimerization on membrane association of Rous sarcoma virus and HIV-1 matrix domain proteins

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30 September 2017

Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle

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Phosphoinositides: tiny lipids with giant impact on cell regulation

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The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress

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30 September 2017

Evidence in support of RNA-mediated inhibition of phosphatidylserine-dependent HIV-1 Gag membrane binding in cells.

1 reference

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30 September 2017

The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells

1 reference

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30 September 2017

The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress

1 reference

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30 September 2017

Assembly of Ebola virus matrix protein VP40 is regulated by latch-like properties of N and C terminal tails

1 reference

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PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity

1 reference

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30 September 2017

Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis

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Sensing phosphatidylserine in cellular membranes

1 reference

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Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels

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Ebola haemorrhagic fever

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30 September 2017

Raster image correlation spectroscopy in live cells

1 reference

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Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen

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Oligomerization of Ebola virus VP40 is essential for particle morphogenesis and regulation of viral transcription

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Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain

1 reference

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Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.

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Structure of the Myristylated Human Immunodeficiency Virus Type 2 Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Membrane Targeting

1 reference

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Membrane phosphatidylserine regulates surface charge and protein localization

1 reference

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1 reference

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1 reference

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Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions.

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Metabolism and functions of phosphatidylserine

1 reference

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Association of ebola virus matrix protein VP40 with microtubules

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Crystal structure of the matrix protein VP40 from Ebola virus

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis.

1 reference

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Targeting of murine leukemia virus gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the matrix

1 reference

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21 September 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/26753796

12 December 2020

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inferred from PubMed ID database lookup

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10.1038/SREP19125

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26753796%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26753796%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26753796%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

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