(Q36474949)

14 August 2017

1 reference

title

Development of receptor-specific opioid peptide analogues (English)

1 reference

14 August 2017

6 Development of Receptor-Specific Opioid Peptide Analogues (English)

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

author name string

P. W. Schiller

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1668844

24 October 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1668844

24 October 2022

publication date

1 January 1991

1 reference

Progress in medicinal chemistry

14 August 2017

published in

1 reference

14 August 2017

volume

28

1 reference

14 August 2017

page(s)

301-340

1 reference

Identification of two related pentapeptides from the brain with potent opiate agonist activity

14 August 2017

cites work

1

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Opioid peptide processing and receptor selectivity

24 October 2022

2

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

AMINO ACID COMPOSITION AND SEQUENCE OF DERMORPHIN, A NOVEL OPIATE-LIKE PEPTIDE FROM THE SKIN OF PHYLLOMEDUSA SAUVAGEI

24 October 2022

3

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites

24 October 2022

4

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Morphiceptin (NH 4 -Tyr-Pro-Phe-Pro-COHN 2 ): a Potent and Specific Agonist for Morphine (μ) Receptors

24 October 2022

6

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Endogenous opioid peptides: multiple agonists and receptors

24 October 2022

8

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Classification of multiple morphine and enkephalin binding sites in the central nervous system

24 October 2022

9

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A highly selective ligand for brain delta opiate receptors, a cyclopropyl(E)Phe(4)-enkephalin analog, suppresses mu receptor-mediated thermal analgesia by morphine

24 October 2022

10

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors

24 October 2022

11

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide

24 October 2022

16

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

U-50488H, a pure kappa receptor agonist with spinal analgesic loci in the mouse

24 October 2022

18

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

[3H]U-69593 a highly selective ligand for the opioid kappa receptor

24 October 2022

19

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A novel series of potent and selective agonists at the opioid kappa-receptor

24 October 2022

20

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

PD117302: a selective agonist for the kappa-opioid receptor

24 October 2022

21

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives

24 October 2022

22

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists

24 October 2022

23

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists

24 October 2022

24

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

(D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic

24 October 2022

25

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity

24 October 2022

26

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Structure-Activity Relationships of Enkephalin-Like Peptides

24 October 2022

27

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Recent developments in the design of receptor specific opioid peptides

24 October 2022

31

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

32

25

337

James

1984

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin

24 October 2022

34

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

35

36

265

Goldstein

1989

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

24 October 2022

36

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

24 October 2022

37

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A novel cyclic opioid peptide analog showing high preference for mu-receptors

24 October 2022

38

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides

24 October 2022

39

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Super-active enkephalin analogues. Simple tripeptide hydroxyalkylamides exhibit surprisingly high and long-lasting opioid activities.

24 October 2022

41

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Syndyphalin SD‐25: a higly selective ligand for μ opiate receptors

24 October 2022

42

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Further enhancment of analgesic activity: enkephalin analogs with terminal guanidino group

24 October 2022

43

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with mu- and delta-receptors

24 October 2022

45

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Central and peripheral action of enkephalin analogues.

24 October 2022

46

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Increased affinity and selectivity of enkephalin tripeptide (Tyr-D-Ala-Gly) dimers.

24 October 2022

48

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Metkephamid, a Systemically Active Analog of Methionine Enkephalin with Potent Opioid δ-Receptor Activity

24 October 2022

50

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and activity profiles of new dermorphin-(1-4) peptide analogues

24 October 2022

51

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

The analgesic activity of D-Arg2-dermorphin and its N-terminal tetrapeptide analogs after subcutaneous administration in mice

24 October 2022

53

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity

24 October 2022

54

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Lysine substitution increases mu-selectivity of potent di- and tri-peptide enkephalin analogs.

24 October 2022

55

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Derivatives of beta-casomorphins with high analgesic potency

24 October 2022

57

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Molecular mechanism of opioid receptor selection

24 October 2022

59

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Comparison of mu-, delta- and kappa-receptor binding sites through pharmacologic evaluation of p-nitrophenylalanine analogs of opioid peptides

24 October 2022

62

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Cluster formation of opiate (enkephalin) receptors in neuroblastoma cells: differences between agonists and antagonists and possible relationships to biological functions

24 October 2022

63

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Interaction of dimers of inactive enkephalin fragments with mu opiate receptors

24 October 2022

64

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A cyclic enkephalin analog with high in vitro opiate activity

24 October 2022

67

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Opiate receptor subclasses differ in their conformational requirements

24 October 2022

68

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogs: effect of conformational constraints on opiate receptor selectivity

24 October 2022

69

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Cyclic and acyclic partial retro-inverso enkephalinamides: Mu receptor selective enzyme resistant analogs

24 October 2022

71

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Biological activities of cyclic enkephalin pseudopeptides containing thioamides as amide bond replacements

24 October 2022

72

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position

24 October 2022

73

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Conformation-activity relationships of cyclic dermorphin analogues

24 October 2022

77

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Structural requirements for opioid activity of analogues of the enkephalins

24 October 2022

79

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates.

24 October 2022

80

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

D-Tyr-Ser-Gly-Phe-Leu-Thr, a highly preferential ligand for δ-opiate receptors

24 October 2022

82

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors

24 October 2022

83

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: a new highly potent and fully specific agonist for opiate delta-receptors

24 October 2022

84

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

delta EPhe4-enkephalin analogs. Delta receptors in rat brain are different from those in mouse vas deferens

24 October 2022

85

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors

24 October 2022

87

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

88

35

774

Amiche

1989

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

89

21

558

Shimohigashi

1982

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Increased affinity of dimeric enkephalins is not dependent on receptor density

24 October 2022

90

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Dimeric tetrapeptide enkephalins display extraordinary selectivity for the delta opiate receptor.

24 October 2022

91

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Cyclic enkephalin analogs containing a cystine bridge.

24 October 2022

94

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

24 October 2022

96

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

97

31

599

Mosberg

1987

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors

24 October 2022

99

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high delta opioid receptor selectivity and affinity

24 October 2022

100

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

D-PRO10dynorphin-(1–11) is a highly potent and selective ligand for ϰ opioid receptors

24 October 2022

101

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

24 October 2022

102

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and biological activity of dynorphin-(1-13) and analogs substituted in positions 8 and 10.

24 October 2022

103

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

"DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites

24 October 2022

104

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Comparative structure-function studies with analogs of dynorphin-(1–13) and [Leu5] enkephalin

24 October 2022

106

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Generalization tests with intraventricularly applied pro-enkephalin B-derived peptides in rats trained to discriminate the opioid kappa receptor agonist ethylketocyclazocine

24 October 2022

107

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Opiate antagonistic properties of an octapeptide somatostatin analog

24 October 2022

111

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity

24 October 2022

112

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors

24 October 2022

113

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Design and synthesis of somatostatin analogues with topographical properties that lead to highly potent and specific mu opioid receptor antagonists with greatly reduced binding at somatostatin receptors

24 October 2022

114

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Mu-opiate binding and morphine antagonism by octapeptide analogs of somatostatin

24 October 2022

115

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Divergent structure activity relationships in series of enkephalin agonists and cognate antagonists

24 October 2022

116

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Selective antagonists at the opiate delta-receptor

24 October 2022

117

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor

24 October 2022

118

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

24 October 2022

119

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and biological activity of analogs of dynorphin-A(1-13) substituted in positions 2 and 4: design of [Ala2,Trp4]-Dyn-A(1-13) as a putative selective opioid antagonist

24 October 2022

122

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties

24 October 2022

123

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

N,N-diallyl-tyrosyl substitution confers antagonist properties on the kappa-selective opioid peptide [D-Pro10]dynorphin A(1-11)

24 October 2022

124

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis and pharmacologic characterization of an alkylating analog chlornaltrexamine, of naltrexone with ultralong-lasting narcotic antagonist properties

24 October 2022

125

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone

24 October 2022

126

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for .mu. or .delta. opiate receptors

24 October 2022

127

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity

24 October 2022

128

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro

24 October 2022

129

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Covalent labeling of opioid receptors with 3H-D-Ala2-Leu5-enkephalin chloromethyl ketone. I. Binding characteristics in rat brain membranes

24 October 2022

131

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Identification of an opioid receptor subunit carrying the .mu. binding site

24 October 2022

132

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Tyr-D-Ala-Gly-(Me)Phe-chloromethyl ketone: a mu specific affinity label for the opioid receptor

24 October 2022

133

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Highly selective photoaffinity labeling of mu and delta opioid receptors

24 October 2022

135

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Synthesis of highly mu and delta opioid receptor selective peptides containing a photoaffinity group

24 October 2022

136

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Photoinactivation of the mu opioid receptor using a novel synthetic morphiceptin analog

24 October 2022

137

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Photoaffinity labeling of opioid receptor of rat brain membranes with 125I(D-Ala2, p-N3-Phe4-Met5)enkephalin

24 October 2022

138

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A photoaffinity reagent to label the opiate receptors of guinea pig ileum and mouse vas deferens

24 October 2022

140

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Fluorescent and photo-affinity enkephalin derivatives: Preparation and interaction with opiate receptors

24 October 2022

141

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Effects of the synthetic enkephalin analogue FK 33-824 in man

24 October 2022

143

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Human tolerability studies with D-Met2,Pro5-enkephalinamide

24 October 2022

145

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

II - Prostaglandin hyperalgesia: The peripheral analgesic activity of morphine, enkephalins and opioid antagonists

24 October 2022

146

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Peripheral antinociceptive effects of N-methyl morphine.

24 October 2022

147

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Antinociceptive effects of mu- and kappa-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism

24 October 2022

148

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Peripherally acting enkephalin analogs. 1. Polar pentapeptides

24 October 2022

149

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions

24 October 2022

150

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe(4NO2)�Pro�NH2 (BW443C)] in healthy volunteers

24 October 2022

151

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Peripherally acting enkephalin analogues. 2. Polar tri- and tetrapeptides

24 October 2022

152

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Control of chemotherapy-induced diarrhea with the synthetic enkephalin BW942C: a randomized trial with placebo in patients receiving cisplatin

24 October 2022

153

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

Influence of metenkephalin analogue on motor activity of the gastrointestinal tract.

24 October 2022

155

1 reference

https://api.crossref.org/works/10.1016/S0079-6468(08)70367-9

24 October 2022

Identifiers

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1668844

24 October 2022

1 reference