(Q36479252)

English

Mechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1 reference

10 October 2019

Mechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

circulatory system

1 reference

10 October 2019

pathophysiology

1 reference

based on heuristic

inferred from title

author name string

T Alexander Quinn

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Peter Kohl

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

publication date

21 August 2012

2 references

Europe PubMed Central

PMC publication ID

14 August 2017

10 October 2019

Progress in Biophysics and Molecular Biology

2 references

Europe PubMed Central

PMC publication ID

14 August 2017

10 October 2019

110

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

2-3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

257-268

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

1 reference

Europe PubMed Central

10 October 2019

Perturbed voltage-gated channel activity in perturbed bilayers: implications for ectopic arrhythmias arising from damaged membrane.

1 reference

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An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation

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Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity

1 reference

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HCN channels and heart rate

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Circadian rhythms govern cardiac repolarization and arrhythmogenesis

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Systems biology of the heart: hype or hope?

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The case for the funny current and the calcium clock.

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Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.

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The funny current has a major pacemaking role in the sinus node

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The funny current in the context of the coupled-clock pacemaker cell system.

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Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets

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Competing oscillators in cardiac pacemaking: historical background

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Systems biology: an approach.

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Cardiac Purkinje cells

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'And the beat goes on.' The cardiac conduction system: the wiring system of the heart.

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What keeps us ticking: a funny current, a calcium clock, or both?

1 reference

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Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate

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The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapy

1 reference

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Inhomogeneity in the response to mechanical stimulation: cardiac muscle function and gene expression

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Responses of single-ventricular myocytes to dynamic axial stretching

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Sarcomere mechanics in uniform and non-uniform cardiac muscle: a link between pump function and arrhythmias.

1 reference

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Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function

1 reference

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1 reference

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New insights into pacemaker activity: promoting understanding of sick sinus syndrome

1 reference

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SCN5A and sinoatrial node pacemaker function.

1 reference

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Heart rate variability in myocardial infarction and heart failure

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Calcium influx through If channels in rat ventricular myocytes.

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I(f) and the biological pacemaker

1 reference

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1 reference

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Species- and preparation-dependence of stretch effects on sino-atrial node pacemaking

1 reference

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1 reference

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Mechanosensitivity of N-type calcium channel currents

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Cardiac excitation-contraction coupling

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Cardiac pacemaking in the sinoatrial node

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Autoregulation of chronotropic response of the heart through pacemaker stretch

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1 reference

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1 reference

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Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation.

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Variation in effects of Cs+, UL-FS-49, and ZD-7288 within sinoatrial node.

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28 June 2018

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28 June 2018

Mechanosensitive gating of atrial ATP-sensitive potassium channels

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28 June 2018

Effects of localized stretch of the sinoatrial node region of the dog heart

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28 June 2018

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28 June 2018

Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells

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28 June 2018

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21 September 2018

Tertiapin-Q removes a mechanosensitive component of muscarinic control of the sinoatrial pacemaker in the rat.

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load.

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21 September 2018

TRPC1 forms the stretch-activated cation channel in vertebrate cells.

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21 September 2018

Effects of lidocaine and verapamil on early afterdepolarizations in isolated rabbit sinoatrial node.

1 reference

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Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

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Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

1 reference

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21 September 2018

Selected contribution: axial stretch increases spontaneous pacemaker activity in rabbit isolated sinoatrial node cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Effects of nicardipine and bupivacaine on early after depolarization in rabbit sinoatrial node cells: a possible mechanism of bupivacaine-induced arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Contribution to heart rate variability by mechanoelectric feedback. Stretch of the sinoatrial node reduces heart rate variability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Intrinsic cardiac rate regulation in the anaesthetized rabbit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Developmental changes in impulse conduction in the canine heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Mechanisms of automaticity in subsidiary pacemakers from cat right atrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526794

21 September 2018

Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of mechanical loading on early conduction system differentiation in the chick

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discordance between microneurographic and heart-rate spectral indices of sympathetic activity in pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stretch activated ion channels in ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical remodeling of the atria following loss of atrioventricular synchrony: a long-term study in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valsalva manoeuvre for supraventricular tachycardia in transplanted heart recipient

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Length-dependent changes of pacemaker frequency in the isolated rabbit sinoatrial node

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stretch‐activated anion currents of rabbit cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHANGES IN THE RESTING POTENTIAL AND THE CABLE PROPERTIES OF PURKINJE FIBERS DURING STRETCH

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological properties in chronic lone atrial fibrillation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological effect of varied rate and extent of acute in vivo left ventricular load increase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of stretch on the isolated cat sinoatrial node

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical spectrum of the sick sinus syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium and Na+-Ca2+ exchange current in isolated toad pacemaker cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of Cl- channels and Ca2+ mobilization in stretch-induced increase of SA node pacemaker activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of the quiescent heart tube to mechanical stretch in the intact chick embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of chronic right atrial stretch on atrial electrical remodeling in patients with an atrial septal defect

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium and mechanically induced potentials in fibroblasts of rat atrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of venous filling upon the rate of the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiological study of the two main pacemaker mechanisms in the rabbit sinus node

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EFFECTS OF STRETCH ON THE SPONTANEOUSLY BEATING, ISOLATED SINUS NODE

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical Remodeling of the Atria in Congestive Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Autonomously promoted extension effect in Purkinje fibers, papillary muscles and trabeculae carneae of rhesus monkeys]

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sheep cardiac Purkinje fibers: configurational changes during the cardiac cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Swelling-induced decrease in spontaneous pacemaker activity of rabbit isolated sino-atrial node cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of stretch on conduction velocity and cable properties of cardiac Purkinje fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intrinsic rate response of the isolated right atrium of the rat, Rattus norvegicus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive chronotropic effect of increasing right atrial pressure in the isolated mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into genetic causes of sinus node disease and atrial fibrillation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanisms of coupling in adrenaline-induced bigeminy in sensitized hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomic substrate for idiopathic left ventricular tachycardia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of right atrial pressure on the cardiac pacemaker response to vagal stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Effect of stretch on action potentials and mechanogram of the heart muscle]

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial stretch alters twitch characteristics and Ca2+ loading of sarcoplasmic reticulum in rat ventricular muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of changes in transmural pressure on contraction frequency of the isolated right atrium of the rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ageing-dependent remodelling of ion channel and Ca2+clock genes underlying sino-atrial node pacemaking

1 reference

https://pubmed.ncbi.nlm.nih.gov/23046620

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.PBIOMOLBIO.2012.08.008

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

0 references

Sitelinks

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