(Q36489191)

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Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats (English)

1 reference

Europe PubMed Central

14 August 2017

0 references

author name string

Hongwei Si

1

1 reference

Europe PubMed Central

14 August 2017

Dongmin Liu

2

1 reference

Europe PubMed Central

14 August 2017

language of work or name

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publication date

1 February 2008

1 reference

Europe PubMed Central

14 August 2017

Journal of Nutrition

1 reference

Europe PubMed Central

14 August 2017

138

1 reference

Europe PubMed Central

14 August 2017

2

1 reference

Europe PubMed Central

14 August 2017

297-304

1 reference

Europe PubMed Central

14 August 2017

Phytoestrogens and cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Phytoestrogens as cardioprotective agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Cardiovascular effects of the phytoestrogen genistein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5'-monophosphate-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Estrogen-related receptor α1 up-regulates endothelial nitric oxide synthase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Estrogen plus progestin and the risk of coronary heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Blood pressure, arterial function, structure, and aging: the role of hormonal replacement therapy in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Estrogen modulation of endothelial nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study(1-4).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Phyto-oestrogens and cardiovascular disease risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Soybean phytoestrogen intake and cancer risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

30 September 2017

The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

28 June 2018

Alterations of nitric oxide synthase expression with aging and hypertension in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

28 June 2018

Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Effects of soy isoflavones on endothelial function in healthy postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Genistein activates the 3',5'-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance--the obese middle-aged and the spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Phytoestrogens inhibit growth and MAP kinase activity in human aortic smooth muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Similarities of genetic (spontaneous) hypertension. Man and rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2263007

21 September 2018

Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron overload in hypercholesterolemic rats affects iron homeostasis and serum lipids but not blood pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome and hormones: an integrated approach to gender differences in physiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombotic role of nitric oxide in rats under physiological conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioavailability of soybean isoflavones depends upon gut microflora in women

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant activity of phytoestrogenic isoflavones

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Antiatherogenic effects of endothelium-derived relaxing factor (nitric oxide)]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of soy isoflavones on atherosclerosis: potential mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of antioxidant and antiinflammatory activity of nitric oxide in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18203895

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/JN/138.2.297

0 references

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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