(Q36492499)

14 August 2017

Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. (English)

1 reference

14 August 2017

Troy C Krzysiak

1

1 reference

14 August 2017

Michael Grabe

series ordinal

2

1 reference

14 August 2017

Susan P Gilbert

series ordinal

3

1 reference

14 August 2017

language of work or name

English

0 references

publication date

25 November 2007

1 reference

Journal of Biological Chemistry

14 August 2017

1 reference

14 August 2017

283

1 reference

14 August 2017

2078-2087

1 reference

14 August 2017

4

1 reference

Genes required for mitotic spindle assembly in Drosophila S2 cells

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A structural model for monastrol inhibition of dimeric kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Inhibitors of kinesin motor proteins--research and clinical progress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Mechanistic analysis of the mitotic kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Antitumor activity of a kinesin inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Spindle mechanics and dynamics during mitosis in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

Kinesin's second step

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Inhibition of a mitotic motor protein: where, how, and conformational consequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A force balance model of early spindle pole separation in Drosophila embryos.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A structural change in the kinesin motor protein that drives motility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The kinesin-like protein KLP61F is essential for mitosis in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Pathway of processive ATP hydrolysis by kinesin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Kinesin ATPase: rate-limiting ADP release

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Bead movement by single kinesin molecules studied with optical tweezers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Mitotic spindle organization by a plus-end-directed microtubule motor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Stepping and stretching. How kinesin uses internal strain to walk processively

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Alternating site mechanism of the kinesin ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Movement of microtubules by single kinesin molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Docking and rolling, a model of how the mitotic motor Eg5 works

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

A mechanistic model for Ncd directionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Fluorescence methods for studying the kinetics and thermodynamics of transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Modulation of Kinesin Half-Site ADP Release and Kinetic Processivity by a Spacer between the Head Groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Kinetic studies of dimeric Ncd: evidence that Ncd is not processive

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interacting head mechanism of microtubule-kinesin ATPase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M708354200

1 reference

14 August 2017

1 reference

14 August 2017

1 reference