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The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα
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PMC publication ID
3533472
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10 March 2020
title
The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRα
(English)
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PMC publication ID
3533472
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10 March 2020
main subject
proteolysis
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Isabel González-Mariscal
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2
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3533472
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10 March 2020
Morten Scheibye-Knudsen
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3
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3533472
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10 March 2020
Michel Bernier
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5
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3533472
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10 March 2020
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Susan M Krzysik-Walker
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10 March 2020
Fred E Indig
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4
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3533472
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10 March 2020
publication date
12 October 2012
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10 March 2020
published in
Molecular Pharmacology
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3533472
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10 March 2020
volume
83
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10 March 2020
issue
1
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10 March 2020
page(s)
157-166
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10 March 2020
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AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies
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Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus
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30 September 2017
3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism
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Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability
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CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
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SUMOylation of Blimp-1 promotes its proteasomal degradation
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Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha
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Estrogen related receptors (ERRs): a new dawn in transcriptional control of mitochondrial gene networks
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30 September 2017
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors
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PubMed Central
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30 September 2017
The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein
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Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases
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An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha
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30 September 2017
Pharmacological characterization of GPR55, a putative cannabinoid receptor
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PubMed Central
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30 September 2017
N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies
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PubMed Central
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30 September 2017
Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet
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30 September 2017
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands
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30 September 2017
Absence of estrogen receptor-related-alpha increases osteoblastic differentiation and cancellous bone mineral density
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30 September 2017
Mitochondria and energetic depression in cell pathophysiology
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30 September 2017
ERRalpha: a metabolic function for the oldest orphan
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533472
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30 September 2017
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
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PubMed Central
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30 September 2017
Transcriptional control of energy homeostasis by the estrogen-related receptors
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Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression
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30 September 2017
Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif
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30 September 2017
Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha
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30 September 2017
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
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CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
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Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha
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Constitutive Activation of Transcription and Binding of Coactivator by Estrogen-Related Receptors 1 and 2
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30 September 2017
The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.
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1 reference
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reference URL
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Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice
1 reference
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21 September 2018
Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene.
1 reference
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reference URL
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retrieved
21 September 2018
Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533472
retrieved
21 September 2018
Analysis of protein-DNA binding by streptavidin-agarose pulldown
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23066093
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sumoylation as a signal for polyubiquitylation and proteasomal degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23066093
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Estrogen-related receptors as emerging targets in cancer and metabolic disorders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23066093
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1124/MOL.112.082651
1 reference
stated in
Europe PubMed Central
PMC publication ID
3533472
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23066093%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PMC publication ID
3533472
1 reference
stated in
Europe PubMed Central
PMC publication ID
3533472
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23066093%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PubMed publication ID
23066093
1 reference
stated in
Europe PubMed Central
PMC publication ID
3533472
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23066093%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
ResearchGate publication ID
232248283
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