(Q36500191)

14 August 2017

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title

The therapeutic potential of neural stem cells (English)

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14 August 2017

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Gianvito Martino

1

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14 August 2017

Stefano Pluchino

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 May 2006

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Nature Reviews Neuroscience

14 August 2017

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14 August 2017

7

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14 August 2017

5

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14 August 2017

395-406

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https://scigraph.springernature.com/pub.10.1038/nrn1908

14 August 2017

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cites work

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GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

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Radial glia give rise to adult neural stem cells in the subventricular zone

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

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Multipotent progenitor cells in the adult dentate gyrus.

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Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo

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Adult neurogenesis in the mammalian central nervous system

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Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy

21 January 2018

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Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice

21 January 2018

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Neurogenesis by progenitor cells in the ischemic adult rat hippocampus

21 January 2018

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Transient focal cerebral ischemia-induced neurogenesis in the dentate gyrus of the adult mouse

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Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat.

21 January 2018

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Gene expression changes after focal stroke, traumatic brain and spinal cord injuries

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Adult stem cell therapy in stroke

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Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

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Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.

21 January 2018

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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

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Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.

21 January 2018

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Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis.

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Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells

21 January 2018

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Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation

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Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.

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Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

21 January 2018

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Stem and progenitor cell-based therapy of the human central nervous system.

21 January 2018

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Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells

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Basic fibroblast growth factor support of human embryonic stem cell self-renewal

21 January 2018

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Derivation of human embryonic stem cells in defined conditions

21 January 2018

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Neural stem cells: an overview

21 January 2018

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Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas

21 January 2018

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Gene therapy: can neural stem cells deliver?

21 January 2018

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Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.

21 January 2018

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Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis

21 January 2018

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Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage.

21 January 2018

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Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia.

21 January 2018

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Intravenously injected neural progenitor cells of transgenic rats can migrate to the injured spinal cord and differentiate into neurons, astrocytes and oligodendrocytes.

21 January 2018

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Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats

21 January 2018

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The chemokine system in neuroinflammation: an update

21 January 2018

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Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis

21 January 2018

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Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells

21 January 2018

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Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

21 January 2018

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Regulation of neural progenitor proliferation and survival by beta1 integrins

21 January 2018

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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway

21 January 2018

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Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain.

21 January 2018

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Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies

21 January 2018

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Neuroprotective properties of cultured neural progenitor cells are associated with the production of sonic hedgehog

21 January 2018

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Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline

21 January 2018

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Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons

21 January 2018

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Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

21 January 2018

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Human neural stem cell transplants improve motor function in a rat model of Huntington's disease

21 January 2018

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Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation.

21 January 2018

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Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

21 January 2018

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Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia

21 January 2018

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Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.

21 January 2018

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Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury

21 January 2018

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Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

21 January 2018

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Transplanted neural stem cells promote axonal regeneration through chronically denervated peripheral nerves.

21 January 2018

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Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.

21 January 2018

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The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue

21 January 2018

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Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.

21 January 2018

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Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice

21 January 2018

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Stem cell niche: structure and function

21 January 2018

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Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.

21 January 2018

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Human mesenchymal stem cells modulate B-cell functions

21 January 2018

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Is there a neural stem cell in the mammalian forebrain?

21 January 2018

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Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain

21 January 2018

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Vascular niche for adult hippocampal neurogenesis

21 January 2018

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Anatomy of the brain neurogenic zones revisited: fractones and the fibroblast/macrophage network

21 January 2018

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Establishment in culture of pluripotential cells from mouse embryos

21 January 2018

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Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

21 January 2018

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Isolation of a primate embryonic stem cell line

21 January 2018

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Embryonic stem cell lines derived from human blastocysts

21 January 2018

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Mouse embryonic stem cells exhibit indefinite proliferative potential.

21 January 2018

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Niche-independent symmetrical self-renewal of a mammalian tissue stem cell

21 January 2018

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In vitro differentiation of transplantable neural precursors from human embryonic stem cells

21 January 2018

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Neural progenitors from human embryonic stem cells.

21 January 2018

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Embryonic stem cell-derived glial precursors: a source of myelinating transplants

21 January 2018

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Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury

21 January 2018

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Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

21 January 2018

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Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation.

21 January 2018

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Neuroectodermal differentiation from mouse multipotent adult progenitor cells

21 January 2018

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Neurospheres induced from bone marrow stromal cells are multipotent for differentiation into neuron, astrocyte, and oligodendrocyte phenotypes.

21 January 2018

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A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential

21 January 2018

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Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells

21 January 2018

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Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells

21 January 2018

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Neurogenic differentiation of murine and human adipose-derived stromal cells

21 January 2018

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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

21 January 2018

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Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells

21 January 2018

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Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

21 January 2018

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Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate

21 January 2018

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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

21 January 2018

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Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

21 January 2018

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Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C.

21 January 2018

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Tenascin-R and C in multiple sclerosis lesions: relevance to extracellular matrix remodelling.

21 January 2018

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Chemokines promote quiescence and survival of human neural progenitor cells

21 January 2018

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Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer

21 January 2018

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Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment.

21 January 2018

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Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

21 January 2018

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Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells

21 January 2018

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The differentiation potential of human foetal neuronal progenitor cells in vitro.

21 January 2018

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Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

21 January 2018

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Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?

21 January 2018

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Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived neurotrophic factor in human monocytes.

21 January 2018

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Endogenous and exogenous ciliary neurotrophic factor enhances forebrain neurogenesis in adult mice

21 January 2018

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Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production.

21 January 2018

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Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat.

21 January 2018

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A potential role for erythropoietin in focal permanent cerebral ischemia in mice.

21 January 2018

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GDNF promotes neuronal differentiation and dopaminergic development of mouse mesencephalic neurospheres

21 January 2018

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Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy

21 January 2018

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Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells

21 January 2018

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Platelet-derived growth factor induces chemotaxis of neuroepithelial stem cells.

21 January 2018

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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

21 January 2018

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VEGF is a chemoattractant for FGF-2-stimulated neural progenitors

21 January 2018

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Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

21 January 2018

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Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats.

21 January 2018

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Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord

21 January 2018

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Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury.

21 January 2018

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Neural stem cell grafts reduce the extent of neuronal damage in a mouse model of global ischaemia

21 January 2018

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Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures.

21 January 2018

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Human neural stem cell transplantation in the MPTP-lesioned mouse

21 January 2018

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Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease.

21 January 2018

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Decrease in expression of alpha 5 beta 1 integrin during neuronal differentiation of cortical progenitor cells

21 January 2018

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MCP-1 induces migration of adult neural stem cells.

21 January 2018

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Oligodendrocyte progenitor migration in response to injury of glial monolayers requires the polysialic neural cell-adhesion molecule.

21 January 2018

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Migrating and myelinating potential of neural precursors engineered to overexpress PSA-NCAM.

21 January 2018

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Control of vascular cell adhesion molecule-1 gene promoter activity during neural differentiation

21 January 2018

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Cytokine and chemokine inter-regulation in the inflamed or injured CNS

21 January 2018

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Neural stem cells and their use as therapeutic tool in neurological disorders

21 January 2018

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Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.

31 March 2020

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Cell biology. Ready or not? Human ES cells head toward the clinic

31 March 2020

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Astrocytes give rise to new neurons in the adult mammalian hippocampus.

31 March 2020

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Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain

31 March 2020

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Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

31 March 2020

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Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation

31 March 2020

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Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain

31 March 2020

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Periventricular lesions in multiple sclerosis: their perivenous origin and relationship to granular ependymitis

31 March 2020

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Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.

31 March 2020

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Differential expression of cell fate determinants in neurons and glial cells of adult mouse spinal cord after compression injury

31 March 2020

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Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism.

31 March 2020

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Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.

31 March 2020

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SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury

31 March 2020

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BDNF enhances the differentiation but not the survival of CNS stem cell-derived neuronal precursors

31 March 2020

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BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?

31 March 2020

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Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells.

31 March 2020

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Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor.

31 March 2020

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PDGF and its receptors following facial nerve axotomy in rats: expression in neurons and surrounding glia

31 March 2020

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Platelet-derived growth factor-alpha receptor-positive oligodendroglia are frequent in multiple sclerosis lesions

31 March 2020

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Sequential expression of transforming growth factor-beta1 by T-cells, macrophages, and microglia in rat spinal cord during autoimmune inflammation

31 March 2020

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Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor

31 March 2020

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Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum

31 March 2020

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CD44 expression identifies astrocyte-restricted precursor cells

31 March 2020

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Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN1908

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Dimensions Publication ID

14 August 2017

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