(Q36536770)

English

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index.

scientific article published on August 2006

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842594%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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Europe PubMed Central

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index (English)

1 reference

Europe PubMed Central

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27 December 2019

4

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27 December 2019

author name string

Heike Schäcke

1

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27 December 2019

Hartmut Rehwinkel

2

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27 December 2019

Khusru Asadullah

3

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27 December 2019

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1 August 2006

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27 December 2019

Experimental Dermatology

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27 December 2019

15

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27 December 2019

8

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27 December 2019

565-573

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27 December 2019

Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions

1 reference

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21 January 2018

Mechanisms involved in the side effects of glucocorticoids

1 reference

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21 January 2018

New and improved glucocorticoid receptor ligands

1 reference

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21 January 2018

Adverse effects of topical glucocorticosteroids

1 reference

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Efficacy and safety of inhaled corticosteroids. New developments

1 reference

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21 January 2018

Soft steroids: a new approach to the treatment of inflammatory airways diseases

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21 January 2018

Review of the unique properties of budesonide

1 reference

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21 January 2018

BAG-1 family of cochaperones in the modulation of nuclear receptor action.

1 reference

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21 January 2018

Dynamic remodeling of transcription complexes by molecular chaperones

1 reference

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21 January 2018

Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation

1 reference

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21 January 2018

DNA binding of the glucocorticoid receptor is not essential for survival

1 reference

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21 January 2018

The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin

1 reference

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21 January 2018

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

1 reference

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21 January 2018

The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression

1 reference

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21 January 2018

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

1 reference

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21 January 2018

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex

1 reference

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21 January 2018

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

1 reference

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21 January 2018

The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters

1 reference

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21 January 2018

Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones

1 reference

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21 January 2018

Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

1 reference

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21 January 2018

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Post-transcriptional and nongenomic effects of glucocorticoids.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Functional interactions between Stat5 and the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

MIF as a glucocorticoid-induced modulator of cytokine production

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0625.2006.00453.X

21 January 2018

Glucocorticoid induced the expression of mRNA and the secretion of lipocortin 1 in rat astrocytoma cells.

1 reference

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21 January 2018

The Glucocorticoid Receptor: Molecular Mechanism and New Therapeutic Opportunities

1 reference

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21 January 2018

Is AL-438 likely to have fewer side effects than the glucocorticoids?

1 reference

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21 January 2018

The pursuit of differentiated ligands for the glucocorticoid receptor

1 reference

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21 January 2018

The glucocorticoid receptor as target for classic and novel anti-inflammatory therapy

1 reference

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21 January 2018

Novel ligands: fine tuning the transcriptional activity of the glucocorticoid receptor

1 reference

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21 January 2018

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

1 reference

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21 January 2018

Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo

1 reference

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21 January 2018

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

1 reference

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21 January 2018

A nonsteroidal glucocorticoid receptor antagonist

1 reference

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21 January 2018

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

1 reference

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21 January 2018

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

1 reference

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21 January 2018

Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells

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21 January 2018

Drug discovery for inflammatory diseases

1 reference

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21 January 2018

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity

1 reference

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21 January 2018

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy

1 reference

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21 January 2018

Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand

1 reference

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21 January 2018

A fully dissociated compound of plant origin for inflammatory gene repression

1 reference

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21 January 2018

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