(Q36543729)

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Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1

scientific article published on 4 December 2012

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Europe PubMed Central

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19 February 2020

Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1 (English)

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19 February 2020

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19 February 2020

Grigori Y Rychkov

5

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19 February 2020

Christine Peinelt

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19 February 2020

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Tatiana Kilch

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19 February 2020

Martin Peglow

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19 February 2020

Kathrin Dörr

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19 February 2020

Heiko Rieger

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19 February 2020

Barbara A Niemeyer

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19 February 2020

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4 December 2012

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19 February 2020

Journal of Biological Chemistry

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19 February 2020

288

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19 February 2020

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19 February 2020

1653-1664

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19 February 2020

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11 June 2022

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Immunodeficiency due to defects in store-operated calcium entry

1 reference

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Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

1 reference

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30 September 2017

ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance.

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ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

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30 September 2017

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

1 reference

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30 September 2017

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

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30 September 2017

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI

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Glycosylation in immune cell trafficking

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30 September 2017

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

1 reference

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30 September 2017

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

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30 September 2017

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

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30 September 2017

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

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30 September 2017

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry

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30 September 2017

Mammalian glycosylation in immunity

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Hair loss and defective T- and B-cell function in mice lacking ORAI1

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The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

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A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype

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Novel role for STIM1 as a trigger for calcium influx factor production

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30 September 2017

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

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30 September 2017

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

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Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels

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Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

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Identifiers

10.1074/JBC.M112.417246

1 reference

Europe PubMed Central

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19 February 2020

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19 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23212906%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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