(Q36547383)

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Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer

scientific article published on 13 November 2015

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Europe PubMed Central

PMC publication ID

14 August 2017

Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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based on heuristic

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pharmacodynamics

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7 June 2020

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Kristen P Bunch

2

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7 June 2020

Jin-Qiu Chen

3

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7 June 2020

Michelle A Herrmann

4

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7 June 2020

Jung-Min Lee

5

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7 June 2020

Elise C Kohn

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7 June 2020

Ciara C O'Sullivan

7

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7 June 2020

Elizabeth Jordan

8

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7 June 2020

Nicole Houston

9

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7 June 2020

Naoko Takebe

10

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7 June 2020

Robert J Kinders

11

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7 June 2020

Liang Cao

12

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7 June 2020

Cody J Peer

13

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7 June 2020

W Douglas Figg

14

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7 June 2020

Christina M Annunziata

15

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7 June 2020

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13 November 2015

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14 August 2017

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7 June 2020

122

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7 June 2020

4

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7 June 2020

588-597

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26566079%20AND%20SRC:MED&resulttype=core&format=json

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Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study.

1 reference

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30 September 2017

Smac mimetics as IAP antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.

1 reference

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Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Distinct expression and localization of TNF system in ovarian carcinoma tissues: possible involvement of TNF-α in morphological changes of ovarian cancerous cells

1 reference

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Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer

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Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system

1 reference

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Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL)

1 reference

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30 September 2017

The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

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Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

1 reference

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30 September 2017

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

1 reference

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30 September 2017

Design of small-molecule peptidic and nonpeptidic Smac mimetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Adaptive two-stage designs in phase II clinical trials

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30 September 2017

Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

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IAP family proteins--suppressors of apoptosis

1 reference

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

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Transducers of life and death: TNF receptor superfamily and associated proteins

1 reference

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742409

30 September 2017

Antitumor activity of a novel homodimeric SMAC mimetic in ovarian carcinoma.

1 reference

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Assessment of tumor response as a surrogate endpoint of survival in recurrent/platinum-resistant ovarian carcinoma: a Gynecologic Oncology Group study

1 reference

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1 reference

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7 January 2021

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10.1002/CNCR.29783

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7 June 2020

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Europe PubMed Central

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7 June 2020

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Europe PubMed Central

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7 June 2020

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