(Q36549642)

14 August 2017

1 reference

title

Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease (English)

1 reference

14 August 2017

Mark E Anderson

1

1 reference

PubMed ID

16874356

14 August 2017

Linda S Higgins

series ordinal

2

1 reference

PubMed ID

16874356

14 August 2017

Howard Schulman

series ordinal

3

1 reference

14 August 2017

1 August 2006

1 reference

Nature Clinical Practice Cardiovascular Medicine

14 August 2017

1 reference

14 August 2017

3

1 reference

14 August 2017

437-445

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14 August 2017

8

1 reference

Protein kinases--the major drug targets of the twenty-first century?

14 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Kinomics: methods for deciphering the kinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Beyond mere diversity: tailoring combinatorial libraries for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Library design for fragment based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Protein kinase inhibitors: insights into drug design from structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The conformational plasticity of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Calcium/calmodulin-dependent protein kinase II (CaMKII) localization acts in concert with substrate targeting to create spatial restriction for phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Kinases as therapeutic targets for heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

An essential role of the JAK-STAT pathway in ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

Calmodulin kinase II inhibition protects against structural heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

1 reference

7 January 2021

Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPCARDIO0585

7 January 2021

Identifiers

DOI

10.1038/NCPCARDIO0585

1 reference

14 August 2017

1 reference

PubMed ID

16874356