(Q36549937)

English

Genetic dissection of thyroid hormone receptor beta: identification of mutations that separate hormone binding and transcriptional activation

scientific article published on March 1995

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Genetic dissection of thyroid hormone receptor beta: identification of mutations that separate hormone binding and transcriptional activation (English)

1 reference

Europe PubMed Central

14 August 2017

author name string

R Uppaluri

1

1 reference

Europe PubMed Central

14 August 2017

H C Towle

2

1 reference

Europe PubMed Central

14 August 2017

language of work or name

0 references

publication date

1 March 1995

1 reference

Europe PubMed Central

14 August 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

14 August 2017

15

1 reference

Europe PubMed Central

14 August 2017

1499-1512

1 reference

Europe PubMed Central

14 August 2017

3

1 reference

Europe PubMed Central

14 August 2017

Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Reconstitution of retinoid X receptor function and combinatorial regulation of other nuclear hormone receptors in the yeast Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Structure of the retinoid X receptor alpha DNA binding domain: a helix required for homodimeric DNA binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

RXR-dependent and RXR-independent transactivation by retinoic acid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Nonbiased identification of DNA sequences that bind thyroid hormone receptor alpha 1 with high affinity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Thyroid hormone receptors: multiple forms, multiple possibilities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Mitotic gene conversion lengths, coconversion patterns, and the incidence of reciprocal recombination in a Saccharomyces cerevisiae plasmid system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

The steroid and thyroid hormone receptor superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Immunological abnormalities in insulin receptors on cultured EBV-transformed lymphocytes from insulin-resistant patient with leprechaunism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

30 September 2017

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Functional domains of the human glucocorticoid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Determinants of target gene specificity for steroid/thyroid hormone receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Rat liver c-erbA β1 thyroid hormone receptor is a constitutive activator in yeast (Saccharomyces cerevisiae): Essential role of domains D,E and F in hormone-independent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Correlations of language abnormalities with localization of mutations in the beta-thyroid hormone receptor in 13 kindreds with generalized resistance to thyroid hormone: identification of four new mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

Depletion of L-3,5,3'-Triiodothyronine and L-Thyroxine in Euthyroid Calf Serum for Use in Cell Culture Studies of the Action of Thyroid Hormone*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

28 June 2018

The D domain of the thyroid hormone receptor alpha 1 specifies positive and negative transcriptional regulation functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Conformational changes in chicken thyroid hormone receptor alpha 1 induced by binding to ligand or to DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

A chimeric thyroid hormone receptor constitutively bound to DNA requires retinoid X receptor for hormone-dependent transcriptional activation in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230374

21 September 2018

Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of multiple thyroid hormone response elements located far upstream from the rat S14 promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional synergism between multiple thyroid hormone response elements regulates hepatic expression of the rat S14 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis identifies a new functional domain of the thyroid hormone receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-efficiency transformation of yeast by electroporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vectors for constitutive and inducible gene expression in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thyroid hormone receptor mutations that interfere with transcriptional activation also interfere with receptor interaction with a nuclear protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Powerful dominant negative mutants of the human estrogen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to thyroid hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Filter-binding assay procedure for thyroid hormone receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ty elements transpose through an RNA intermediate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7862143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.15.3.1499

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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0 references

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