(Q36562969)

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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

scientific article published on 31 January 2010

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scholarly article

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17 January 2020

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells (English)

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17 January 2020

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17 January 2020

Lothar Hennighausen

12

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17 January 2020

author name string

Stanley Adoro

2

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17 January 2020

Terry Guinter

3

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17 January 2020

Batu Erman

4

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17 January 2020

Amala S Alag

5

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17 January 2020

Marta Catalfamo

6

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17 January 2020

Motoko Y Kimura

7

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17 January 2020

Yongzhi Cui

8

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17 January 2020

Philip J Lucas

9

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17 January 2020

Ronald E Gress

10

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17 January 2020

Masato Kubo

11

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17 January 2020

Lionel Feigenbaum

13

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17 January 2020

Alfred Singer

14

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17 January 2020

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publication date

31 January 2010

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17 January 2020

Nature Immunology

1 reference

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17 January 2020

11

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17 January 2020

3

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17 January 2020

257-264

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17 January 2020

CD4-CD8 lineage differentiation: Thpok-ing into the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Characterization of the thymic IL-7 niche in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Suppressors of cytokine signaling and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Transient inhibition of interleukin 4 signaling by T cell receptor ligation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

Positive selection of thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

30 September 2017

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555225

28 June 2018

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

In vitro differentiation and commitment of CD4+ CD8+ thymocytes to the CD4 lineage, without TCR engagement.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

A dose effect of IL-7 on thymocyte development

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

CCR7 signals are essential for cortex-medulla migration of developing thymocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

CCR7 directs the migration of thymocytes into the thymic medulla

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNI.1840

21 January 2018

Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny and regulation of IL-7-expressing thymic epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SOCS-1 story

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20118929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/NI.1840

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118929%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118929%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118929%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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