(Q36577165)

15 August 2017

title

Clinical impact of research on the podocyte slit diaphragm (English)

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15 August 2017

Duncan B Johnstone

1

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15 August 2017

Lawrence B Holzman

series ordinal

2

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15 August 2017

publication date

1 May 2006

1 reference

Nature Clinical Practice Nephrology

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

5

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15 August 2017

page(s)

271-282

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Pathophysiology of proteinuria

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

How does the kidney filter plasma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

The permeability of glomerular capillaries to graded dextrans. Identification of the basement membrane as the primary filtration barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin is specifically located at the slit diaphragm of glomerular podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin localizes to the slit pore of the glomerular epithelial cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

What determines glomerular capillary permeability?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Podocin localizes in the kidney to the slit diaphragm area

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Lipid raft domains and protein networks in T-cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Lipid rafts and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

IrreC/rst-mediated cell sorting during Drosophila pupal eye development depends on proper localisation of DE-cadherin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Regulation of cadherin-mediated adhesion in morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Characterization of the interactions of the nephrin intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

IQGAP1: a key regulator of adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

New insights into Fat cadherins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Clinical, histopathologic, and genetic studies in nine families with focal segmental glomerulosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

TRP channels: a TR(I)P through a world of multifunctional cation channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Regulation of TRPC6 channel activity by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Interplay between TCR signalling and actin cytoskeleton dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Association of CD2AP with dynamic actin on vesicles in podocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Cyclosporine in patients with steroid-resistant nephrotic syndrome: an open-label, nonrandomized, retrospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

New insights into the pathogenesis and the therapy of recurrent focal glomerulosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Gene expression analysis of human renal biopsies: recent developments towards molecular diagnosis of kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Gene Expression Profiles of Podocyte-Associated Molecules as Diagnostic Markers in Acquired Proteinuric Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Podocytes that detach in experimental membranous nephropathy are viable.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Messenger RNA expression of glomerular podocyte markers in the urinary sediment of acquired proteinuric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Prospects for urinary proteomics: exosomes as a source of urinary biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

A novel protein, densin, expressed by glomerular podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Actin Filament Organization of Foot Processes in Rat Podocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

Structural determinants of glomerular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

7 January 2021

NEPH1 defines a novel family of podocin interacting proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

7 January 2021

FAT is a component of glomerular slit diaphragms

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

7 January 2021

Congenital nephrotic syndrome in mice lacking CD2-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

7 January 2021

The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0180

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0180

1 reference

15 August 2017

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