(Q36579406)

15 August 2017

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title

How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly (English)

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15 August 2017

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Larissa J Vos

1

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15 August 2017

Jakub K Famulski

series ordinal

2

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15 August 2017

Gordon K T Chan

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3

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15 August 2017

language of work or name

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1 August 2006

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Biochemistry and Cell Biology

15 August 2017

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15 August 2017

84

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15 August 2017

619-639

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15 August 2017

4

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Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31

15 August 2017

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Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

21 January 2018

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Microtubule plus-end-tracking proteins: mechanisms and functions.

21 January 2018

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Chromodomains are protein-RNA interaction modules

21 January 2018

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Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.

21 January 2018

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

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Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila

21 January 2018

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Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod.

21 January 2018

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21 January 2018

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Dicer is essential for mouse development

21 January 2018

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Structural determinants for generating centromeric chromatin

21 January 2018

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Conserved organization of centromeric chromatin in flies and humans

21 January 2018

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Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.

21 January 2018

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Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.

21 January 2018

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Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

21 January 2018

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Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

21 January 2018

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Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

21 January 2018

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Kinetochore structure and function

21 January 2018

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Implication of a novel multiprotein Dam1p complex in outer kinetochore function

21 January 2018

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Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast

21 January 2018

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A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension

21 January 2018

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The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.

21 January 2018

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BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

21 January 2018

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Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

21 January 2018

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Epigenetic regulation by histone methylation and histone variants

21 January 2018

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Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

21 January 2018

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Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression

21 January 2018

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The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

21 January 2018

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Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes

21 January 2018

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Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

21 January 2018

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Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites

21 January 2018

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KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans

21 January 2018

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High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes

21 January 2018

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Centromeric chromatin makes its mark.

21 January 2018

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Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase

21 January 2018

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The HP1 protein family: getting a grip on chromatin

21 January 2018

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Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore

21 January 2018

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Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae

21 January 2018

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Histone variant H2A.Z is required for early mammalian development

21 January 2018

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation

21 January 2018

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The human CENP-A centromeric nucleosome-associated complex

21 January 2018

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Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA.

21 January 2018

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Centromere DNA, proteins and kinetochore assembly in vertebrate cells

21 January 2018

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CENP-C is necessary but not sufficient to induce formation of a functional centromere

21 January 2018

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CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells.

21 January 2018

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Dicer is essential for formation of the heterochromatin structure in vertebrate cells

21 January 2018

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NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae

21 January 2018

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Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast

21 January 2018

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Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway

21 January 2018

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Mouse centric and pericentric satellite repeats form distinct functional heterochromatin

21 January 2018

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RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

21 January 2018

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A species of small antisense RNA in posttranscriptional gene silencing in plants

21 January 2018

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21 January 2018

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The mitotic checkpoint gene BubR1 has two distinct functions in mitosis

21 January 2018

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Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.

21 January 2018

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CENP-G: a new centromeric protein that is associated with the alpha-1 satellite DNA subfamily

21 January 2018

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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

21 January 2018

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Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

21 January 2018

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Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint.

21 January 2018

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Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

21 January 2018

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Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice

21 January 2018

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Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes

21 January 2018

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Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

21 January 2018

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Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle

21 January 2018

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Construction of YAC-based mammalian artificial chromosomes

21 January 2018

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The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

21 January 2018

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Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3.

21 January 2018

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The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control

21 January 2018

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Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation

21 January 2018

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Translating the Histone Code

21 January 2018

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Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

21 January 2018

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Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death

21 January 2018

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The cenpB gene is not essential in mice

21 January 2018

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Chromosomes can congress to the metaphase plate before biorientation

21 January 2018

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A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

21 January 2018

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Evolutionary conservation between budding yeast and human kinetochores

21 January 2018

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Neocentromeres and alpha satellite: a proposed structural code for functional human centromere DNA.

21 January 2018

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ZW10 links mitotic checkpoint signaling to the structural kinetochore.

21 January 2018

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

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The Saccharomyces cerevisiae kinetochore

21 January 2018

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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

21 January 2018

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Role for DNA methylation in genomic imprinting

21 January 2018

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The mitotic spindle is required for loading of the DASH complex onto the kinetochore

21 January 2018

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Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

21 January 2018

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"Holo"er than thou: chromosome segregation and kinetochore function in C. elegans

21 January 2018

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The dynamic kinetochore-microtubule interface

21 January 2018

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Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

21 January 2018

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Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

21 January 2018

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Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

21 January 2018

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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

21 January 2018

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The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment

21 January 2018

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CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells

21 January 2018

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Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore

21 January 2018

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Stretching it: putting the CEN(P-A) in centromere

21 January 2018

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Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

21 January 2018

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The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis

21 January 2018

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Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

21 January 2018

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HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes

21 January 2018

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The constitutive centromere component CENP-50 is required for recovery from spindle damage

21 January 2018

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HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres

21 January 2018

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Centromere protein B assembles human centromeric alpha-satellite DNA at the 17-bp sequence, CENP-B box

21 January 2018

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Epigenetics: interaction of DNA methylation and chromatin

21 January 2018

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Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins

21 January 2018

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Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

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CENP-I is essential for centromere function in vertebrate cells

21 January 2018

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Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast

21 January 2018

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A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

21 January 2018

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Functional analysis of kinetochore assembly in Caenorhabditis elegans.

21 January 2018

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CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA.

21 January 2018

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The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres

21 January 2018

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A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore

21 January 2018

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Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation

21 January 2018

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Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

21 January 2018

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Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

21 January 2018

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RNA interference demonstrates a novel role for H2A.Z in chromosome segregation.

21 January 2018

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Topoisomerase II alpha is associated with the mammalian centromere in a cell cycle- and species-specific manner and is required for proper centromere/kinetochore structure

21 January 2018

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CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization

21 January 2018

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

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CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

21 January 2018

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Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

21 January 2018

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Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

21 January 2018

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Active genes are tri-methylated at K4 of histone H3

21 January 2018

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Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated

21 January 2018

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Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

21 January 2018

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Genomic and genetic definition of a functional human centromere

21 January 2018

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Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

21 January 2018

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Chromatin assembly at kinetochores is uncoupled from DNA replication

21 January 2018

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Conservation of the centromere/kinetochore protein ZW10

21 January 2018

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ZW10 helps recruit dynactin and dynein to the kinetochore

21 January 2018

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 January 2018

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The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

21 January 2018

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Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes

21 January 2018

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Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein

21 January 2018

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Determining centromere identity: cyclical stories and forking paths.

21 January 2018

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Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin

21 January 2018

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Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere

21 January 2018

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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

21 January 2018

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Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality

21 January 2018

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The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

21 January 2018

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In vivo functional dissection of human inner kinetochore protein CENP-C

21 January 2018

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Many paths to the top of the mountain: diverse evolutionary solutions to centromere structure.

21 January 2018

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A histone variant, H2AvD, is essential in Drosophila melanogaster

21 January 2018

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Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

21 January 2018

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Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling

21 January 2018

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Chromosomal dynamics of human neocentromere formation

21 January 2018

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Molecular organization of the Ndc80 complex, an essential kinetochore component

21 January 2018

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Architecture of the budding yeast kinetochore reveals a conserved molecular core

21 January 2018

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The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation

21 January 2018

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Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions

21 January 2018

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Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

21 January 2018

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CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

21 January 2018

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CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

21 January 2018

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Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro

21 January 2018

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Xenopus CENP-A assembly into chromatin requires base excision repair proteins

21 January 2018

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CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

21 January 2018

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

21 January 2018

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The centromere-kinetochore complex: a repeat subunit model

21 January 2018

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Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O06-078

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15 August 2017

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