(Q36598469)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21396468%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis (English)

1 reference

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25 January 2020

0 references

1 reference

13

1 reference

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25 January 2020

author name string

V B Kraus

1

1 reference

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25 January 2020

B Burnett

2

1 reference

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25 January 2020

J Coindreau

3

1 reference

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25 January 2020

S Cottrell

4

1 reference

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25 January 2020

D Eyre

5

1 reference

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25 January 2020

M Gendreau

6

1 reference

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25 January 2020

J Gardiner

7

1 reference

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25 January 2020

P Garnero

8

1 reference

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25 January 2020

J Hardin

9

1 reference

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25 January 2020

Y Henrotin

10

1 reference

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25 January 2020

D Heinegård

11

1 reference

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25 January 2020

A Ko

12

1 reference

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25 January 2020

G Matthews

14

1 reference

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25 January 2020

J Menetski

15

1 reference

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25 January 2020

R Moskowitz

16

1 reference

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25 January 2020

S Persiani

17

1 reference

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25 January 2020

A R Poole

18

1 reference

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25 January 2020

J-C Rousseau

19

1 reference

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25 January 2020

M Todman

20

1 reference

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25 January 2020

OARSI FDA Osteoarthritis Biomarkers Working Group

21

1 reference

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25 January 2020

publication date

23 March 2011

1 reference

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Osteoarthritis and Cartilage

25 January 2020

published in

1 reference

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25 January 2020

volume

19

1 reference

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25 January 2020

issue

5

1 reference

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25 January 2020

page(s)

515-542

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21396468%20AND%20SRC:MED&resulttype=core&format=json

First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis

25 January 2020

cites work

1 reference

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Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression

9 September 2017

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Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation

9 September 2017

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Collagen biomarkers for arthritis applications.

9 September 2017

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Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers

9 September 2017

1 reference

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Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study

9 September 2017

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9 September 2017

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9 September 2017

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Whither osteoarthritis biomarkers?

9 September 2017

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Variation in osteoarthritis biomarkers from activity not food consumption

9 September 2017

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Banking of biological fluids for studies of disease-associated protein biomarkers

9 September 2017

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The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?

9 September 2017

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Serum protein signatures detect early radiographic osteoarthritis

9 September 2017

1 reference

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One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status

9 September 2017

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PIIANP and HELIXII diurnal variation

9 September 2017

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Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee

9 September 2017

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Joint space narrowing and Kellgren-Lawrence progression in knee osteoarthritis: an analytic literature synthesis

9 September 2017

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Strategic paths for biomarker qualification

9 September 2017

1 reference

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Type II collagen markers in osteoarthritis: what do they indicate?

9 September 2017

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Biological markers in osteoarthritis

9 September 2017

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Monitoring cartilage turnover

9 September 2017

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Biomarker qualification pilot process at the US Food and Drug Administration

9 September 2017

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The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis

9 September 2017

1 reference

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Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema.

9 September 2017

1 reference

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Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study

9 September 2017

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Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis

9 September 2017

1 reference

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Process map proposal for the validation of genomic biomarkers

9 September 2017

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A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients

9 September 2017

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Classification of osteoarthritis biomarkers: a proposed approach.

9 September 2017

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Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis

9 September 2017

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Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study

9 September 2017

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9 September 2017

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Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies

9 September 2017

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Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

9 September 2017

1 reference

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Evidence for altered synthesis of type II collagen in patients with osteoarthritis

9 September 2017

1 reference

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Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis

9 September 2017

1 reference

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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

9 September 2017

1 reference

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Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay

9 September 2017

1 reference

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The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand

9 September 2017

1 reference

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The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.

9 September 2017

1 reference

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Molecular markers of processes in cartilage in joint disease.

9 September 2017

1 reference

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Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay

9 September 2017

1 reference

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Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease

9 September 2017

1 reference

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Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthri

9 September 2017

1 reference

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Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis

30 September 2017

1 reference

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Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers

30 September 2017

1 reference

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The Food and Drug Administration's Osteoporosis Guidance Document: past, present, and future

30 September 2017

1 reference

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Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III.

30 September 2017

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Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association

30 September 2017

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Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice

30 September 2017

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Isolation of microarray-grade total RNA, microRNA, and DNA from a single PAXgene blood RNA tube

28 June 2018

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Blood-based biomarkers for detecting mild osteoarthritis in the human knee.

28 June 2018

1 reference

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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.

28 June 2018

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A study of the relationship between molecular biomarkers of joint degeneration and the magnetic resonance-measured characteristics of cartilage in 16 symptomatic knees

28 June 2018

1 reference

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Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study.

28 June 2018

1 reference

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Quantification of keratan sulfate in blood as a marker of cartilage catabolism

28 June 2018

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Accumulation of hyaluronate in human lung carcinoma as measured by a new hyaluronate ELISA.

28 June 2018

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Analysis of unsaturated disaccharides from glycosaminoglycuronan by high-performance liquid chromatography

28 June 2018

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Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis

28 June 2018

1 reference

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Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease

20 September 2018

1 reference

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Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568396

N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial

20 September 2018

1 reference

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The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation

20 September 2018

1 reference

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Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3568396

Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis

20 September 2018

1 reference

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Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.

20 September 2018

1 reference

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Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.

20 September 2018

1 reference

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Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis.

20 September 2018

1 reference

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Effect of anticoagulants on the determination of plasma matrix metalloproteinase (MMP)-2 and MMP-9 activities

20 September 2018

1 reference

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The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases

20 September 2018

1 reference

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Modulation of collagen fibrillogenesis by dentinal proteoglycans.

20 September 2018

1 reference

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OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.

20 September 2018

1 reference

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Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate.

20 September 2018

1 reference

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Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.

20 September 2018

1 reference

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Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative.

20 September 2018

1 reference

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Urea as a passive transport marker for arthritis biomarker studies

20 September 2018

1 reference

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Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradation

20 September 2018

1 reference

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Circadian variation in serum CrossLaps concentration is reduced in fasting individuals.

20 September 2018

1 reference

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Plasma hyaluronan concentration: no circadian rhythm but large effect of food intake in humans.

20 September 2018

1 reference

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Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degeneration

20 September 2018

1 reference

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Change in joint space width: Hyaline articular cartilage loss or alteration in meniscus?

20 September 2018

1 reference

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Soy protein may alleviate osteoarthritis symptoms

4 December 2018

1 reference

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Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY study

4 December 2018

1 reference

12 December 2020

Kellgren & Lawrence grade 1 osteophytes in the knee--doubtful or definite?

1 reference

12 December 2020

Assessment of the utility of biomarkers of osteoarthritis in the guinea pig

1 reference

12 December 2020

Optimization of the fixed-flexion knee radiograph

1 reference

12 December 2020

Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis

1 reference

12 December 2020

Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury

1 reference

12 December 2020

Feasibility of simultaneous measurement of bone formation and bone resorption markers to assess bone turnover rate in postmenopausal women: an EPOLOS study

1 reference

12 December 2020

Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis

1 reference

12 December 2020

Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints

1 reference

12 December 2020

Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic joint fluid

1 reference

12 December 2020

Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

1 reference

12 December 2020

COMP acts as a catalyst in collagen fibrillogenesis

1 reference

12 December 2020

Content and sulfation pattern of keratan sulfate in hip osteoarthritis using high performance liquid chromatography

1 reference

12 December 2020

Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis

1 reference

12 December 2020

Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years

1 reference

12 December 2020

Collagen type II C-telopeptide fragments as an index of cartilage degradation

1 reference

12 December 2020

A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis

1 reference

12 December 2020

Early Rheumatoid-Like Lesions in Rabbits Injected with Foreign Serum: Relationship to Localization of Immune Complexes in the Lining Tissues of Joints and Cellular Content of Synovial Fluid

1 reference

12 December 2020

Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing

1 reference

12 December 2020

Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation

1 reference

12 December 2020

Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease

1 reference

12 December 2020

Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor

1 reference

12 December 2020

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston county osteoarthritis project

1 reference

12 December 2020

Early changes in serum type ii collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy

1 reference

12 December 2020

Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs

1 reference

12 December 2020

10.1016/J.JOCA.2010.08.019

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21396468%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21396468%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

21396468

1 reference