(Q36604899)

15 August 2017

On roads not taken in the evolution of protein catalysts: antibody steroid isomerases that use an enamine mechanism (English)

1 reference

15 August 2017

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C H Lin

1

1 reference

15 August 2017

T Z Hoffman

2

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15 August 2017

P Wirsching

3

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15 August 2017

C F Barbas

4

1 reference

15 August 2017

K D Janda

5

1 reference

15 August 2017

R A Lerner

6

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15 August 2017

language of work or name

English

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publication date

1 October 1997

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Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

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15 August 2017

94

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15 August 2017

11773-11776

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15 August 2017

22

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15 August 2017

EVOLUTION OF ALDOLASE

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Solution structure of 3-oxo-delta5-steroid isomerase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Mechanism of the reaction catalyzed by acetoacetate decarboxylase. Importance of lysine 116 in determining the pKa of active-site lysine 115

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

A data-based reaction mechanism for type I fructose bisphosphate aldolase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Influence of the position of the double bond in steroid substrates on the efficiency of the proton-transfer reaction by Pseudomonas testosteroni 3-oxo-steroid delta 4-delta 5-isomerase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Fructose-bisphosphate aldolases: an evolutionary history

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

The Δ5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Nature of the intermediate in the 3-oxo-delta 5-steroid isomerase reaction

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Primary amino catalysis of the isomerization of a .beta.,.gamma.-unsaturated ketone to its .alpha.,.beta.-unsaturated isomer. Possible method for enzymic double bond migration in unsaturated ketones

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

A catalytic antibody isomerizing a delta 5-3-cétostéroïde.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23568

Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction

20 September 2018

1 reference

12 December 2020

Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects

1 reference

12 December 2020

Lysine-146 of rabbit muscle aldolase is essential for cleavage and condensation of the C3-C4 bond of fructose 1,6-bis(phosphate)

1 reference

12 December 2020

Reactive immunization

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.94.22.11773

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15 August 2017

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15 August 2017

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