(Q36609738)

15 August 2017

1 reference

title

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy (English)

1 reference

15 August 2017

0 references

1 reference

1 reference

Ichiro Ieiri

1

1 reference

15 August 2017

Hiroshi Takane

2

1 reference

15 August 2017

Takeshi Hirota

3

1 reference

15 August 2017

Kenji Otsubo

4

1 reference

15 August 2017

Shun Higuchi

5

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 October 2006

1 reference

Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

24

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

15 August 2017

2

1 reference

15 August 2017

651-674

1 reference

15 August 2017

5

1 reference

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Expression of a multidrug-resistance gene in human tumors and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Novel mechanisms of drug resistance in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The multispecific organic anion transporter family: properties and pharmacological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Cloning and characterization of two human polyspecific organic cation transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Drugs as P-glycoprotein substrates, inhibitors, and inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The ATP-dependent glutathione S-conjugate export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Genetic analysis of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Characterization of the human MDR1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Breast carcinoma tumor characteristics in black and white women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

MDR1 genotype-related pharmacokinetics: fact or fiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Effect of ABCG2 genotype on the oral bioavailability of topotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

MDR1 gene expression in brain of patients with medically intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Multidrug-resistance protein 1 in focal cortical dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The C3435T polymorphism of MDR1 and susceptibility to adult glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

MDR-1 C3435T polymorphism influences cyclosporine a dose requirement in liver-transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.5.651

21 January 2018

Identifiers

DOI

10.1517/17425255.2.5.651

1 reference

15 August 2017

1 reference