(Q36612188)

English

A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia.

scientific article published on 18 July 2006

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

author name string

Zohar S

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Bardin C

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Vekhoff A

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Chaoui D

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Rio B

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Legrand O

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Sentenac S

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Rousselot P

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Raffoux E

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Chast F

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Marie JP

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

language of work or name

0 references

publication date

18 July 2006

1 reference

Europe PubMed Central

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27 December 2019

British Journal of Cancer

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

95

1 reference

Europe PubMed Central

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27 December 2019

253-259

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

describes a project that uses

1 reference

Europe PubMed Central

18 June 2022

https://europepmc.org/article/PMC/2360653

based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6603265

0 references

Experimental designs for phase I and phase I/II dose-finding studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Software to compute and conduct sequential Bayesian phase I or II dose-ranging clinical trials with stopping rules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Homoharringtonine: history, current research, and future direction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Acute myeloid leukaemia (AML): treatment of the older patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Chronic myelogenous leukemia--progress at the M. D. Anderson Cancer Center over the past two decades and future directions: first Emil J Freireich Award Lecture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Homoharringtonine: an effective new natural product in cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Phase I trial of homoharringtonine administered as a 5-day continuous infusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Phase I clinical investigation of homoharringtonine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Cephalotaxine esters: antileukemic advance or therapeutic failure?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Phase II study of low-dose continuous infusion homoharringtonine in refractory acute myelogenous leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Inhibition of Translation in Eukaryotic Systems by Harringtonine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

30 September 2017

Long-term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group experience.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Homoharringtonine: an effective new drug for remission induction in refractory nonlymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Effect of homoharringtonine on the viability of murine leukemia P388 cells resistant to either adriamycin, vincristine, or 1-beta-D-arabinofuranosylcytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Influence of harringtonine on human leukemia cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Alkaloid homoharringtonine inhibits polypeptide chain elongation on human ribosomes on the step of peptide bond formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Continual reassessment method: a practical design for phase 1 clinical trials in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Homoharringtonine is safe and effective for patients with acute myelogenous leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

28 June 2018

Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

20 September 2018

Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

20 September 2018

The continual reassessment method: comparison of Bayesian stopping rules for dose-ranging studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2360653

20 September 2018

The continual reassessment method for dose-finding studies: a tutorial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6603265

21 January 2018

Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homoharringtonine in combination with cytarabine for patients with acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Harringtonine, an inhibitor of initiation of protein biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of homoharringtonine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biologic and pharmacologic effects of harringtonine on human leukemia-lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homoharringtonine: a phase I evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of homoharringtonine administered by prolonged continuous infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of homoharringtonine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of homoharringtonine alone and in combination with alpha interferon and cytosine arabinoside on 'in vitro' growth and induction of apoptosis in chronic myeloid leukemia and normal hematopoietic progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16847470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6603265

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16847470%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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