(Q36615843)

English

Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.

scientific article published on May 2005

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Valdemar Maximo

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

9

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Manuel Sobrinho Simões

12

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10 January 2020

author name string

T Botelho

2

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Europe PubMed Central

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10 January 2020

J Capela

3

1 reference

Europe PubMed Central

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10 January 2020

A Taveira

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

T Amaro

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

A P Barbosa

8

1 reference

Europe PubMed Central

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10 January 2020

H R Harach

10

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10 January 2020

D Williams

11

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10 January 2020

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publication date

1 May 2005

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Europe PubMed Central

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10 January 2020

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

92

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1892-1898

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602547

0 references

GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Endonuclease G is an apoptotic DNase when released from mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Chromosomal localization of human GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Stat3 as an oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Solitary, multiple, and familial oxyphil tumours of the thyroid gland

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Interleukin-6-specific activation of the C/EBPdelta gene in hepatocytes is mediated by Stat3 and Sp1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

30 September 2017

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

20 September 2018

Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

20 September 2018

Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2361763

20 September 2018

Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benign and malignant oncocytoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis off hurthle cell papillary thyroid carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA 'common' deletion in Hürthle cell lesions of the thyroid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF Mutation in Papillary Thyroid Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF mutations are associated with some histological types of papillary thyroid carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hürthle cell and mitochondrion-rich papillary carcinomas of the thyroid gland: an ultrastructural and immunocytochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hürthle-cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of nuclear and mitochondrial DNA alterations in thyroid and renal oncocytic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15841082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6602547

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15841082%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

ResearchGate publication ID

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