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English
The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation.
scientific article published on January 2006
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
main subject
anakinra
1 reference
based on heuristic
inferred from title
author
Claire Jacques
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
Marjolaine Gosset
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
author name string
Francis Berenbaum
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
Cem Gabay
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
publication date
1 January 2006
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
published in
Vitamins and Hormones
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
volume
74
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
page(s)
371-403
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
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Interleukin-1 receptor antagonist: role in biology
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Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention
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Functional genomic analysis of type II IL-1beta decoy receptor: potential for gene therapy in human arthritis and inflammation
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7 January 2021
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Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee
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7 January 2021
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Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
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7 January 2021
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Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer
1 reference
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Crossref
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7 January 2021
based on heuristic
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Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma
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Crossref
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7 January 2021
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Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on PGE2 production by articular chondrocytes does not involve PLA2 stimulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1beta and tumor necrosis factor-alpha produce distinct, time-dependent patterns of acute arthritis in the rat knee
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
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Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
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https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor alpha blockade
1 reference
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https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor
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7 January 2021
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Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains
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reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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inferred from DOI database lookup
TRAF6 is a signal transducer for interleukin-1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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inferred from DOI database lookup
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
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7 January 2021
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Metalloproteinase inhibitors and the prevention of connective tissue breakdown
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide attenuates cellular hexose monophosphate shunt response to oxidants in articular chondrocytes and acts to promote oxidant injury
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
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inferred from DOI database lookup
The role of nitric oxide in inflammation and immunity
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament
1 reference
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Crossref
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7 January 2021
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ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
1 reference
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Crossref
reference URL
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7 January 2021
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The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.
1 reference
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Crossref
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7 January 2021
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Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells
1 reference
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Crossref
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7 January 2021
based on heuristic
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Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
The effects of treatment with interleukin-1 receptor antagonist on the inflamed synovial membrane in rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of soluble interleukin-1 type II receptor on rabbit antigen-induced arthritis: clinical, biochemical and histological assessment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The PPARalpha-leukotriene B4 pathway to inflammation control.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal cartilage structure, biochemistry, and metabolism: a review of the literature.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine traps: multi-component, high-affinity blockers of cytokine action
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid responses to anakinra in patients with refractory adult-onset Still's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of ADAMTS homologues in articular cartilage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Osteoarthritis and cartilage: the role of cytokines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional suppression by interleukin-1 and interferon-gamma of type II collagen gene expression in human chondrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Collagen Gene Expression by Prostaglandins and Interleukin-1beta in Cultured Chondrocytes and Fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Matrix metalloproteinases: the clue to intervertebral disc degeneration?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Open label trial of anakinra in active ankylosing spondylitis over 24 weeks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of nuclear receptors by prostaglandins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 3' untranslated region of the membrane-bound IL-1R accessory protein mRNA confers tissue-specific destabilization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unresponsiveness of MyD88-deficient mice to endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression profiling of metalloproteinases and their inhibitors in cartilage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-1 beta protects human chondrocytes from CD95-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of experimental arthritis by gene transfer of interleukin 1 receptor antagonist cDNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Production of intracellular IL-1alpha, IL-1beta, and IL-1Ra isoforms by activated human dermal and synovial fibroblasts: phenotypic differences between human dermal and synovial fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of hypoxia and reoxygenation on gene expression and response to interleukin-1 in cultured articular chondrocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggrecanases and cartilage matrix degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PPA250 [3-(2,4-difluorophenyl)-6-[2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy]-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of ch
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preliminary results of safety and efficacy of the interleukin 1 receptor antagonist anakinra in patients with severe lupus arthritis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice transgenic for intracellular interleukin-1 receptor antagonist type 1 are protected from collagen-induced arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of nitric oxide synthase in human chondrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ADAMTS metalloproteinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cartilage protection by nitric oxide synthase inhibitors after intraarticular injection of interleukin-1beta in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo expression of inflammatory cytokine receptors in the joint compartments of patients with arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The two interleukin-1 receptors play different roles in IL-1 actions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric-Oxide Mediates Suppression of Cartilage Proteoglycan Synthesis by Interleukin-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection of an interleukin-1 intracellular receptor antagonist mRNA variant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0083-6729%2806%2974016-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0083-6729(06)74016-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
PubMed publication ID
17027524
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17027524
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17027524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 December 2019
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