(Q36620480)

15 August 2017

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title

Disease modifying genes in cystic fibrosis: therapeutic option or one-way road? (English)

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15 August 2017

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Rainer Büscher

1

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PubMed ID

17033796

15 August 2017

Hartmut Grasemann

series ordinal

2

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15 August 2017

11 October 2006

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Naunyn-Schmiedeberg's Archives of Pharmacology

15 August 2017

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15 August 2017

374

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15 August 2017

2

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15 August 2017

65-77

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https://scigraph.springernature.com/pub.10.1007/s00210-006-0101-2

15 August 2017

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cites work

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1 reference

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Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Are lymphocyte beta-adrenoceptors altered in patients with cystic fibrosis?

21 January 2018

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Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: cohort study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma

21 January 2018

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Alpha 1-antitrypsin deficiency: evaluation of bronchiectasis with CT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Pharmacotherapy of the ion transport defect in cystic fibrosis: role of purinergic receptor agonists and other potential therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Pharmacological approaches to correcting the ion transport defect in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Levels of free granulocyte elastase in bronchial secretions from patients with cystic fibrosis: effect of antimicrobial treatment against Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

An investigation of polymorphism in the interleukin-10 gene promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Detoxication enzymes and chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-006-0101-2

Beta-adrenoceptor polymorphisms

21 January 2018

1 reference

12 December 2020

Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease.

1 reference

12 December 2020

Inhalation of alpha(1)-protease inhibitor in cystic fibrosis does not affect surfactant convertase and surface activity

1 reference

12 December 2020

Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage

1 reference

12 December 2020

Association of a Missense Mutation in theNOS3Gene with Exhaled Nitric Oxide Levels

1 reference

12 December 2020

Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma

1 reference

12 December 2020

Glutathione-S-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis

1 reference

12 December 2020

Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype

1 reference

12 December 2020

Human adrenoceptor polymorphisms: evolving recognition of clinical importance

1 reference

12 December 2020

Glutathione S-transferase polymorphisms in MS: their relationship to disability

1 reference

12 December 2020

Long-acting bronchodilators in cystic fibrosis

1 reference

12 December 2020

Normal alveolar epithelial lining fluid contains high levels of glutathione

1 reference

12 December 2020

End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms.

1 reference

12 December 2020

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity

1 reference

12 December 2020

Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship

1 reference

12 December 2020

Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene

1 reference

12 December 2020

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).

1 reference

12 December 2020

Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease

1 reference

12 December 2020

Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR).

1 reference

12 December 2020

Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis

1 reference

12 December 2020

Reduced upper airway nitric oxide in cystic fibrosis

1 reference

12 December 2020

The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription.

1 reference

12 December 2020

Alpha1-antitrypsin deficiency alleles and the Taq-I G-->A allele in cystic fibrosis lung disease.

1 reference

12 December 2020

Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study

1 reference

12 December 2020

Genetic control of the circulating concentration of transforming growth factor type beta1

1 reference

12 December 2020

Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease

1 reference

12 December 2020

The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study

1 reference

12 December 2020

Therapeutic approaches to cystic fibrosis: memorandum from a joint WHO/ICF(M)A meeting

1 reference

12 December 2020

Variants of alpha 1-antitrypsin in Puerto Rican children with asthma

1 reference

12 December 2020

Increased arginase activity in cystic fibrosis airways

1 reference

12 December 2020

Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis

1 reference

12 December 2020

Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker

1 reference

12 December 2020

The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1.

1 reference

12 December 2020

Endothelial Nitric Oxide Synthase Variants in Cystic Fibrosis Lung Disease

1 reference

12 December 2020

P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx

1 reference

12 December 2020

Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism

1 reference

12 December 2020

Macromolecular interactions and ion transport in cystic fibrosis

1 reference

12 December 2020

A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.

1 reference

12 December 2020

Beta 2 adrenergic receptor polymorphisms in cystic fibrosis

1 reference

12 December 2020

Modifier genes in cystic fibrosis

1 reference

12 December 2020

Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis

1 reference

12 December 2020

Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women

1 reference

12 December 2020

Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease

1 reference

12 December 2020

Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation.

1 reference

12 December 2020

The TNFα receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis

1 reference

12 December 2020

IL-10 exerts suppressive and enhancing effects on antifungal activity of mononuclear phagocytes against Aspergillus fumigatus

1 reference

12 December 2020

Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease

1 reference

12 December 2020

Genetic modifiers of lung disease in cystic fibrosis

1 reference

12 December 2020

Aquaporin water channels and lung physiology

1 reference

12 December 2020

beta-Adrenergic receptor polymorphisms and response to salmeterol

1 reference

12 December 2020

Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis

1 reference

12 December 2020

Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis

1 reference

12 December 2020

Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study

1 reference

12 December 2020

Role of free radicals in the pathogenesis of cystic fibrosis

1 reference

12 December 2020

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein

1 reference

12 December 2020

Captopril inhibits apoptosis in human lung epithelial cells: a potential antifibrotic mechanism.

1 reference

12 December 2020

Cystic fibrosis lung disease: the role of nitric oxide

1 reference

12 December 2020

A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis

1 reference

12 December 2020

Studies in alpha 1-antitrypsin deficiency.

1 reference

12 December 2020

Association of alpha(1)-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis

1 reference

12 December 2020

Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis

1 reference

12 December 2020

Decreased systemic bioavailability of L-arginine in patients with cystic fibrosis

1 reference

12 December 2020

Delta F508 genotype does not predict disease severity in an ethnically diverse cystic fibrosis population

1 reference

12 December 2020

Randomized, double-blind, placebo-controlled, dose-escalating study of aerosolized interferon gamma-1b in patients with mild to moderate cystic fibrosis lung disease

1 reference

12 December 2020

Evidence that alveolar macrophages can synthesize and secrete alpha 1-antichymotrypsin

1 reference

12 December 2020

Bronchodilator action of inhaled nitric oxide in guinea pigs

1 reference

12 December 2020

Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease

1 reference

12 December 2020

The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma

1 reference

12 December 2020

Pulmonary oxidative stress response in young children with cystic fibrosis

1 reference

12 December 2020

Categories of deltaF508 homozygous cystic fibrosis twin and sibling pairs with distinct phenotypic characteristics.

1 reference

12 December 2020

Genotype-phenotype relationships in cystic fibrosis

1 reference

12 December 2020

Association of polymorphism in glutathione S-transferase loci with susceptibility and outcome in rheumatoid arthritis: comparison with the shared epitope.

1 reference

12 December 2020

Contribution of genetic factors other than CFTR to disease severity in cystic fibrosis

1 reference

12 December 2020

Bringing new treatments to the bedside in cystic fibrosis

1 reference

12 December 2020

Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases

1 reference

12 December 2020

Plasma markers of platelet activation in cystic fibrosis liver and lung disease

1 reference

12 December 2020

TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis

1 reference

12 December 2020

Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors--evolving concepts and clinical implications

1 reference

12 December 2020

[Cystic fibrosis modifying genes]

1 reference

12 December 2020

Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis

1 reference

12 December 2020

α1-Antitrypsin Deficiency Alleles in Cystic Fibrosis Lung Disease

1 reference

12 December 2020

Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide.

1 reference

12 December 2020

Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis.

1 reference

12 December 2020

Dornase alpha and exhaled NO in cystic fibrosis.

1 reference

12 December 2020

A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer.

1 reference

12 December 2020

Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism

1 reference

12 December 2020

Sputum tumour necrosis factor-alpha and leukotriene concentrations in cystic fibrosis

1 reference

12 December 2020

Transforming growth factor-beta1 and lung allograft fibrosis.

1 reference

12 December 2020

The relation between genotype and phenotype in cystic fibrosis--analysis of the most common mutation (delta F508).

1 reference

12 December 2020

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix

1 reference

12 December 2020

Population variation of common cystic fibrosis mutations. The Cystic Fibrosis Genetic Analysis Consortium

1 reference

12 December 2020

Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer

1 reference

12 December 2020

Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats

1 reference

12 December 2020

Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation

1 reference

12 December 2020

Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway

1 reference

12 December 2020

Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis

1 reference

12 December 2020

Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis

1 reference

12 December 2020

An alpha1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary outcome in cystic fibrosis.

1 reference

12 December 2020

Transforming growth factor-beta1 genotype and susceptibility to chronic obstructive pulmonary disease

1 reference

12 December 2020

Nitric oxide metabolites in cystic fibrosis lung disease

1 reference

12 December 2020

Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis.

1 reference

12 December 2020

NO pathway in CF and non-CF children.

1 reference

12 December 2020

Mannose binding protein gene mutations associated with unusual and severe infections in adults

1 reference

12 December 2020

Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis

1 reference

12 December 2020

beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease

1 reference

12 December 2020

Allotypes of alpha 1-antitrypsin in patients with cystic fibrosis, homozygous and heterozygous for deltaF508

1 reference

12 December 2020

Glutathione S-transferase polymorphisms and their biological consequences

1 reference

12 December 2020

Exhaled nitric oxide in patients with asthma: association with NOS1 genotype

1 reference

12 December 2020

Effect of L-arginine infusion on airway NO in cystic fibrosis and primary ciliary dyskinesia syndrome

1 reference

12 December 2020

IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice

1 reference

12 December 2020

Interleukin-10 (IL-10) genotypes in inflammatory bowel disease

1 reference

12 December 2020

Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans

1 reference

12 December 2020

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

1 reference

12 December 2020

10.1007/S00210-006-0101-2

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17033796