(Q36621449)

15 August 2017

Characterization of a genetically engineered inactivation-resistant coagulation factor VIIIa (English)

1 reference

15 August 2017

S W Pipe

1

1 reference

15 August 2017

R J Kaufman

series ordinal

2

1 reference

15 August 2017

language of work or name

English

0 references

publication date

1 October 1997

1 reference

Proceedings of the National Academy of Sciences of the United States of America

15 August 2017

1 reference

15 August 2017

94

1 reference

15 August 2017

22

1 reference

15 August 2017

11851-11856

1 reference

Ca2+ binding to the first epidermal growth factor-like domain of human blood coagulation factor IX promotes enzyme activity and factor VIII light chain binding.

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Molecular cloning of a cDNA encoding human antihaemophilic factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Structure of human factor VIII

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

30 September 2017

https://api.crossref.org/works/10.1073%2FPNAS.94.22.11851

Structure-function relationship of human von Willebrand factor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Role of the B domain for factor VIII and factor V expression and function.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Site-directed mutagenesis and expression of coagulation factors VIII and V in mammalian cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

The size of human factor VIII heterodimers and the effects produced by thrombin

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

pH-dependent denaturation of thrombin-activated porcine factor VIII.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Structural and functional characterization of Factor VIII-delta II, a new recombinant Factor VIII lacking most of the B-domain

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Proteolytic inactivation of human factor VIII procoagulant protein by activated human protein C and its analogy with factor V.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Mutations of factor VIII cleavage sites in hemophilia A.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Stable expression of recombinant factor VIII molecules using a bovine papillomavirus vector

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=23634

Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity

20 September 2018

1 reference

12 December 2020

Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis

1 reference

12 December 2020

The role of phospholipid and factor VIIIa in the activation of bovine factor X

1 reference

12 December 2020

The role of factor VIII in the activation of human blood coagulation factor X by activated factor IX

1 reference

12 December 2020

The effect of thrombin on the complex between factor VIII and von Willebrand factor

1 reference

12 December 2020

Subunit structure of thrombin-activated human factor VIIIa

1 reference

12 December 2020

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells

1 reference

12 December 2020

A new recombinant procoagulant protein derived from the cDNA encoding human factor VIII

1 reference

12 December 2020

The effect of von Willebrand factor on activation of factor VIII by factor Xa

1 reference

12 December 2020

Vectors used for expression in mammalian cells

1 reference

12 December 2020

von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation

1 reference

12 December 2020

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1 reference

12 December 2020

The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets

1 reference

12 December 2020

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity

1 reference

12 December 2020

Epitope localization of monoclonal antibodies against factor VIII light chain which inhibit complex formation by factor VIII with von Willebrand factor

1 reference

12 December 2020

Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa

1 reference

12 December 2020

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1 reference

12 December 2020

Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site

1 reference

12 December 2020

Localization of factor IXa and factor VIIIa interactive sites

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.94.22.11851

1 reference

15 August 2017

0 references

1 reference

15 August 2017

PubMed publication ID

9342326

1 reference