(Q36625248)

15 August 2017

1 reference

title

Glucocorticoid action and the development of selective glucocorticoid receptor ligands (English)

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15 August 2017

Timothy J Cole

1

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15 August 2017

publication date

1 January 2006

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Biotechnology Annual Review

15 August 2017

published in

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15 August 2017

volume

12

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15 August 2017

page(s)

269-300

1 reference

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions

15 August 2017

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7 January 2021

Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction.

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7 January 2021

Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.

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7 January 2021

A mechanistic basis for distinct mineralocorticoid and glucocorticoid receptor transcriptional specificities

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7 January 2021

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

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7 January 2021

The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

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7 January 2021

The further redefining of steroid-mediated signaling

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7 January 2021

Partial purification and biochemical characterization of a membrane glucocorticoid receptor from an amphibian brain

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7 January 2021

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

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7 January 2021

Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, phosphatidylinositol 3-kinase

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7 January 2021

Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis.

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7 January 2021

Role of transcription factors in fetal lung development and surfactant protein gene expression.

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7 January 2021

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

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7 January 2021

Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

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7 January 2021

Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice.

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7 January 2021

Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice.

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7 January 2021

DNA binding of the glucocorticoid receptor is not essential for survival

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7 January 2021

The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development

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7 January 2021

Corticosteroids and fetal pulmonary maturity

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7 January 2021

Antenatal corticosteroids: the good, the bad and the unknown

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7 January 2021

Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity

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https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Hormones and the stressed brain.

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7 January 2021

Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders

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7 January 2021

Effects of cholinergic lesions produced by infusions of 192 IgG-saporin on glucocorticoid receptor mRNA expression in hippocampus and medial prefrontal cortex of the rat.

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7 January 2021

Stress and cognition: are corticosteroids good or bad guys?

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7 January 2021

Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption.

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7 January 2021

Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability

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7 January 2021

Brain corticosteroid receptor balance in health and disease

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7 January 2021

The acute effects of corticosteroids on cognition: integration of animal and human model studies

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7 January 2021

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7 January 2021

Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety?

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7 January 2021

Pathophysiology of modulation of local glucocorticoid levels by 11beta-hydroxysteroid dehydrogenases

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7 January 2021

Glial cells express both mineralocorticoid and glucocorticoid receptors

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7 January 2021

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

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7 January 2021

Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis.

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7 January 2021

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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7 January 2021

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice

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7 January 2021

Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter

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7 January 2021

Inhibition of IL-2-induced Jak-STAT signaling by glucocorticoids

1 reference

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7 January 2021

Anti-inflammatory actions of steroids: molecular mechanisms

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7 January 2021

Sex steroids, glucocorticoids, stress and autoimmunity

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7 January 2021

Apoptosis and steroid hormones

1 reference

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7 January 2021

Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases.

1 reference

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7 January 2021

Glucocorticoids, lipocortins and the immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor

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7 January 2021

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation

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7 January 2021

Neuroendocrine regulation of immunity

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7 January 2021

Functional interactions between Stat5 and the glucocorticoid receptor

1 reference

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7 January 2021

Crosstalk between the interleukin-6 (IL-6)-JAK-STAT and the glucocorticoid-nuclear receptor pathway: synergistic activation of IL-6 response element by IL-6 and glucocorticoid

1 reference

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7 January 2021

Glucocorticoids down‐regulate dendritic cell function in vitro and in vivo

1 reference

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7 January 2021

Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids

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7 January 2021

Cross-talk between glucocorticoid receptor and AP-1.

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7 January 2021

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

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7 January 2021

Antagonism between Nur77 and glucocorticoid receptor for control of transcription.

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7 January 2021

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

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7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

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7 January 2021

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

1 reference

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7 January 2021

Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways

1 reference

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7 January 2021

A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation

1 reference

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7 January 2021

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

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7 January 2021

Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator

1 reference

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7 January 2021

CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation

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7 January 2021

Role of CBP/P300 in nuclear receptor signalling

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7 January 2021

Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.

1 reference

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7 January 2021

Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene

1 reference

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7 January 2021

Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

1 reference

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7 January 2021

Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possiblein vitro model for positive selection of the T cell repertoire

1 reference

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7 January 2021

A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death

1 reference

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7 January 2021

Steroid production in the thymus: implications for thymocyte selection.

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7 January 2021

Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo

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7 January 2021

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development

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7 January 2021

Glucocorticoids in T cell development and function*.

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7 January 2021

Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice

1 reference

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7 January 2021

Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Partial blockade of T-cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis

1 reference

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7 January 2021

Killing of immature CD4+ CD8+ thymocytes in vivo by anti-CD3 or 5'-(N-ethyl)-carboxamide adenosine is blocked by glucocorticoid receptor antagonist RU-486

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7 January 2021

Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

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7 January 2021

Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling

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7 January 2021

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

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https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Do glucocorticoids participate in thymocyte development?

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Stress-free T-cell development: glucocorticoids are not obligatory

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7 January 2021

Glucocorticoids and the thymus: the view from the middle of the road

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7 January 2021

A role for glucocorticoids in the thymus?

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7 January 2021

Different roles for glucocorticoids in thymocyte homeostasis?

1 reference

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7 January 2021

Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor

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7 January 2021

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

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7 January 2021

Designer glucocorticoids

1 reference

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7 January 2021

Discovery of novel nonsteroidal glucocorticoid receptor modulators

1 reference

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7 January 2021

A nonsteroidal glucocorticoid receptor antagonist

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7 January 2021

RU 486 (mifepristone). A short overview of its mechanisms of action and clinical uses at the end of 1996.

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7 January 2021

Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.

1 reference

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7 January 2021

Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators

1 reference

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7 January 2021

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

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7 January 2021

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore

1 reference

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7 January 2021

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Differential SERM effects on corepressor binding dictate ERalpha activity in vivo

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https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Selective thyroid hormone receptor modulators

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https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

A thyroid hormone antagonist that inhibits thyroid hormone action in vivo

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https://api.crossref.org/works/10.1016%2FS1387-2656%2806%2912008-6

7 January 2021

Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands

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7 January 2021

Atomic structure of progesterone complexed with its receptor

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7 January 2021

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

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7 January 2021

Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor

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7 January 2021

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

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7 January 2021

10.1016/S1387-2656(06)12008-6

Identifiers

DOI

1 reference

15 August 2017

1 reference