(Q36628309)

English

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists

scientific article published on 22 May 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Takashi Yamamoto

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Padma Nair

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Peg Davis

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Shou-wu Ma

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Edita Navratilova

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Sharif Moye

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Suneeta Tumati

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Josephine Lai

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Todd W Vanderah

9

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Henry I Yamamura

10

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Frank Porreca

11

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Victor J Hruby

12

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

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publication date

22 May 2007

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

15 August 2017

50

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2779-2786

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Improving opioid effectiveness: from ideas to evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

New trends in the development of opioid peptide analogues as advanced remedies for pain relief

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

The delta-opioid receptor: molecular pharmacology, signal transduction, and the determination of drug efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

The peptide binding site of the substance P (NK-1) receptor localized by a photoreactive analogue of substance P: presence of a disulfide bond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Antinociceptive profile of biphalin, a dimeric enkephalin analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Metkephamid (Tyr-D-Ala-Gly-Phe-N(Me)Met-NH2), a potent opioid peptide: Receptor binding and analgesic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Spinal opiate analgesia: Characteristics and principles of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Metkephamid, a Systemically Active Analog of Methionine Enkephalin with Potent Opioid δ-Receptor Activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Development of delta opioid peptides as nonaddicting analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Endogenous opioid peptides: multiple agonists and receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

30 September 2017

Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Spinal neurons that possess the substance P receptor are required for the development of central sensitization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Opioid activity of sendide, a tachykinin NK1 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Effects of metkephamid (LY127623), a selective delta opioid receptor agonist, on gastric function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Opioid receptor binding properties of analgesic analogues of cholecystokinin octapeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Topographical requirements for delta opioid ligands: common structural features of dermenkephalin and deltorphin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

28 June 2018

Endomorphins interact with tachykinin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Resting and evoked spinal substance P release during chronic intrathecal morphine infusion: parallels with tolerance and dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Spinal antinociceptive effects of AA501, a novel chimeric peptide with opioid receptor agonist and tachykinin receptor antagonist moieties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Methionine oxidation enhances opioid activity of an enkephalin analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2365895

20 September 2018

Design principles: enkephalins with predictable mu/delta receptor specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmission of chronic nociception by spinal neurons expressing the substance P receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity of normorphine for its pharmacologic receptor in the naive and morphine-tolerant guinea-pig isolated ileum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17516639

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM061369N

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

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