(Q36662723)

English

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin

scientific article published on 3 April 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

0 references

2,7-dihydroxy-5-methyl-1-naphthoic acid

1 reference

ChEBI release 2020-05-28

2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid

1 reference

ChEBI release 2020-05-28

2,7-dihydroxy-5-methyl-1-naphthoate

1 reference

ChEBI release 2020-05-28

2-hydroxy-7-methoxy-5-methyl-1-naphthoate

1 reference

ChEBI release 2020-05-28

5-methyl-1-naphthoic acid

1 reference

ChEBI release 2020-05-28

author name string

Yinggang Luo

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Shuangjun Lin

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jian Zhang

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Heather A Cooke

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Steven D Bruner

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Ben Shen

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

3 April 2008

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

283

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

21

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

14694-14702

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

1 reference

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RebG- and RebM-catalyzed indolocarbazole diversification

1 reference

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30 September 2017

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Truncated azinomycin analogues intercalate into DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

NEOCARZINOSTATIN, AN ANTITUMOR ANTIBIOTIC OF HIGH MOLECULAR WEIGHT. ISOLATION, PHYSIOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

1 reference

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30 September 2017

Characterization of an inducible chlorophenol O-methyltransferase from Trichoderma longibrachiatum involved in the formation of chloroanisoles and determination of its role in cork taint of wines

1 reference

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30 September 2017

A novel Mg(2+)-dependent O-methyltransferase in the phenylpropanoid metabolism of Mesembryanthemum crystallinum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Studies on the mechanism of action of azinomycin B: definition of regioselectivity and sequence selectivity of DNA cross-link formation and clarification of the role of the naphthoate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

The enediyne antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Free radical mechanisms in neocarzinostatin-induced DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

Sequence-specific, strand-selective, and directional binding of neocarzinostatin chromophore to oligodeoxyribonucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

30 September 2017

The S-n-propyl analogue of S-adenosylmethionine

1 reference

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30 September 2017

Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

28 June 2018

Subcellular fate of protein antibiotic neocarzinostatin in culture of a lymphoid cell line from Burkitt's lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

28 June 2018

Molecular cloning and biochemical characterization of indole-3-acetic acid methyltransferase from poplar.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

20 September 2018

Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2386921

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Characterization of O-methyltransferase ScOMT1 cloned from Streptomyces coelicolor A3(2).

1 reference

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On the origin of the DNA sequence selectivity of the azinomycins

1 reference

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Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

1 reference

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DNA cleavage characteristics of non-protein enediyne antibiotic N1999A2.

1 reference

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Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.

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1-Hydroxy-4-methoxy-2-naphthoic acid, a herbicidal compound produced by Streptosporangium cinnabarinum ATCC 31,213.

1 reference

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Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

1 reference

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Hydroxyquinone O-methylation in mitomycin biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

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inferred from PubMed ID database lookup

A Synthetic Azinomycin Analogue with Demonstrated DNA Cross-Linking Activity: Insights into the Mechanism of Action of this Class of Antitumor Agent The authors gratefully acknowledge the financial support provided by the CRC and the EPSRC. We are i

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineating noncovalent interactions between the azinomycins and double-stranded DNA: importance of the naphthalene substitution pattern on interstrand cross-linking efficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphotropic accumulation of an antitumor antibiotic protein, neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocarzinostatin chromophore binds to deoxyribonucleic acid by intercalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method for the rapid synthesis of highly functionalized 2-hydroxy-1-naphthoates. Syntheses of the naphthoic acid components of neocarzinostatin chromophore and N1999A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthetic ligands for apo-neocarzinostatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular model for DNA cross-linking by the antitumor agent azinomycin B

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA binding and alkylation by the "left half" of azinomycin B

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18387946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802206200

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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