(Q36704838)

English

Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey

scientific article published on 11 January 2007

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey (English)

1 reference

Europe PubMed Central

15 August 2017

1 reference

based on heuristic

inferred from title

author name string

Thomas A Waldmann

1

1 reference

Europe PubMed Central

15 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

11 January 2007

1 reference

Europe PubMed Central

15 August 2017

Journal of Clinical Immunology

1 reference

Europe PubMed Central

15 August 2017

27

1 reference

Europe PubMed Central

15 August 2017

1

1 reference

Europe PubMed Central

15 August 2017

1-18

1 reference

Europe PubMed Central

15 August 2017

https://scigraph.springernature.com/pub.10.1007/s10875-006-9060-0

0 references

The soluble interleukin-2 receptor: biology, function, and clinical application

1 reference

https://api.crossref.org/works/10.1007%2FS10875-006-9060-0

21 January 2018

Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab).

1 reference

https://api.crossref.org/works/10.1007%2FS10875-006-9060-0

21 January 2018

Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of acute renal allograft rejection by daclizumab. Daclizumab Double Therapy Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the human interleukin-2 receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daclizumab: a review of its use in the prevention of acute rejection in renal transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multi-subunit interleukin-2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of rejection in cardiac transplantation by blockade of the interleukin-2 receptor with a monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The meandering 45-year odyssey of a clinical immunologist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy in malignant and immune disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daclizumab is associated with decreased rejection and no increased mortality in cardiac transplant patients receiving MMF, cyclosporine, and corticosteroids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 receptor-directed therapies for cutaneous lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanized antibody directed to the IL-2 receptor beta-chain prolongs primate cardiac allograft survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of interleukin 2 receptors on activated human B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of anti-IL-2Ralpha antibody on IL-2-induced Jak/STAT signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A humanized antibody that binds to the interleukin 2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in interleukin 2 receptor targeted treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human IL-2 receptor alpha chain deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2Ralpha interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-2/IL-2 receptor system: a target for rational immune intervention

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient expression of interleukin 2 receptors. Consequences for T cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The safety and efficacy of a two-dose daclizumab (zenapax) induction therapy in liver transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T cell leukemia virus type I (HTLV-I) and human diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human receptor for T-cell growth factor. Evidence for variable post-translational processing, phosphorylation, sulfation, and the ability of precursor forms of the receptor to bind T-cell growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of antibodies against the IL-2 receptor in transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daclizumab: a review of its use in the management of organ transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early experience with anti-Tac in clinical renal transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term safety, tolerability and efficacy of daclizumab (Zenapax) in a two-dose regimen in liver transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous cultures of fused cells secreting antibody of predefined specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas and the art of lymphocyte maintenance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17216565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10875-006-9060-0

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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