(Q36717066)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling (English)

1 reference

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22 February 2020

1 reference

2

1 reference

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22 February 2020

author name string

M J Noetzel

1

1 reference

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22 February 2020

P N Vinson

3

1 reference

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22 February 2020

J T Manka

4

1 reference

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22 February 2020

S R Stauffer

5

1 reference

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22 February 2020

C W Lindsley

6

1 reference

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22 February 2020

C M Niswender

7

1 reference

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22 February 2020

Z Xiang

8

1 reference

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22 February 2020

P J Conn

9

1 reference

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22 February 2020

publication date

24 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

published in

Molecular Pharmacology

1 reference

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22 February 2020

volume

83

1 reference

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22 February 2020

issue

4

1 reference

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22 February 2020

page(s)

835-847

1 reference

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Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

22 February 2020

cites work

1 reference

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Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

30 September 2017

1 reference

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Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

30 September 2017

1 reference

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N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators

30 September 2017

1 reference

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Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

30 September 2017

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Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors

30 September 2017

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Mutations causing syndromic autism define an axis of synaptic pathophysiology

30 September 2017

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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

30 September 2017

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Metabotropic glutamate receptors as therapeutic targets for schizophrenia

30 September 2017

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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

30 September 2017

1 reference

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Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

30 September 2017

1 reference

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Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

30 September 2017

1 reference

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

30 September 2017

1 reference

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Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

30 September 2017

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Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential

30 September 2017

1 reference

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Metabotropic glutamate receptors: physiology, pharmacology, and disease

30 September 2017

1 reference

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Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

30 September 2017

1 reference

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Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

30 September 2017

1 reference

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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

30 September 2017

1 reference

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

30 September 2017

1 reference

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

30 September 2017

1 reference

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Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells

30 September 2017

1 reference

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Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

30 September 2017

1 reference

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

30 September 2017

1 reference

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

30 September 2017

1 reference

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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

30 September 2017

1 reference

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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

30 September 2017

1 reference

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

30 September 2017

1 reference

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A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

30 September 2017

1 reference

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

30 September 2017

1 reference

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

30 September 2017

1 reference

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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

30 September 2017

1 reference

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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

30 September 2017

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608436

Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608436

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608436

Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608436

Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3608436

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

28 June 2018

1 reference

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

28 June 2018

1 reference

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Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors

28 June 2018

1 reference

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5 September 2018

Identifiers

DOI

10.1124/MOL.112.082891

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

23348500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23348500%20AND%20SRC:MED&resulttype=core&format=json