(Q36748519)

16 August 2017

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title

Genetic contributions to type 2 diabetes: recent insights (English)

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16 August 2017

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Michèle M Sale

1

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16 August 2017

Stephen S Rich

series ordinal

2

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16 August 2017

publication date

1 March 2007

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

2

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16 August 2017

page(s)

207-217

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Linkage of calpain 10 to type 2 diabetes: the biological rationale

16 August 2017

cites work

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A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

21 January 2018

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

21 January 2018

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

21 January 2018

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

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Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses

21 January 2018

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A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

21 January 2018

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Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

21 January 2018

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A fat attack occurred in fat city

21 January 2018

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

21 January 2018

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TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

21 January 2018

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Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.

21 January 2018

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Wnt signaling: physiology and pathology

21 January 2018

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New aspects of Wnt signaling pathways in higher vertebrates

21 January 2018

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TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

21 January 2018

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Association of the mu-opioid receptor gene with type 2 diabetes mellitus in an African American population

21 January 2018

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Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity

21 January 2018

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Role of mu-opioid receptors in insulin release in the presence of inhibitory and excitatory secretagogues

21 January 2018

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21 January 2018

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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction

21 January 2018

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High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients

21 January 2018

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Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity

21 January 2018

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Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes

21 January 2018

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Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines

21 January 2018

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Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese

21 January 2018

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The search for type 2 diabetes susceptibility genes using whole-genome scans: an epidemiologist's perspective

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Gigantism in mice lacking suppressor of cytokine signalling-2

21 January 2018

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Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

21 January 2018

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Insulin-like growth factor I and impaired glucose tolerance

21 January 2018

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

21 January 2018

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Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects

21 January 2018

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Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia

21 January 2018

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Retinol-binding protein: the serum transport protein for vitamin A.

21 January 2018

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Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes

21 January 2018

1 reference

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The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai

21 January 2018

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Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans

21 January 2018

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A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes

21 January 2018

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The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans

21 January 2018

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Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients

21 January 2018

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Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects

21 January 2018

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Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes

21 January 2018

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Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study

21 January 2018

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Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism

21 January 2018

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Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population

21 January 2018

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Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

21 January 2018

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Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people

21 January 2018

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

21 January 2018

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Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

21 January 2018

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No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population.

21 January 2018

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Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.

21 January 2018

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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

21 January 2018

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Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha

21 January 2018

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Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

21 January 2018

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Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population.

21 January 2018

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Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians

21 January 2018

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Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes

21 January 2018

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An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance

21 January 2018

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Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians

21 January 2018

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The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes.

21 January 2018

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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

21 January 2018

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Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes.

21 January 2018

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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.

21 January 2018

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Vildagliptin: a novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes

21 January 2018

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mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis

21 January 2018

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Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases

21 January 2018

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Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites

21 January 2018

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In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach

21 January 2018

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Complement factor H polymorphism in age-related macular degeneration

21 January 2018

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Complement factor H polymorphism and age-related macular degeneration

21 January 2018

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

21 January 2018

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

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Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

21 January 2018

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Association Analysis of 6,736 U.K. Subjects Provides Replication and ConfirmsTCF7L2as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual Risk

21 January 2018

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Association of Transcription Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample

21 January 2018

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Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

21 January 2018

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Common Variants in the ENPP1 Gene Are Not Reproducibly Associated With Diabetes or Obesity

21 January 2018

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Preliminary Evidence of FABP2 A54T Polymorphism Associated with Reduced Risk of Type 2 Diabetes and Obesity in Women from a German Cohort

21 January 2018

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Association Between Functional FABP2 Promoter Haplotype and Type 2 Diabetes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/14737159.7.2.207

1 reference

16 August 2017

1 reference