(Q36767089)

English

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.

scientific article published on 10 January 2013

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scholarly article

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21 February 2020

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis (English)

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21 February 2020

Robert Lafyatis

3

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21 February 2020

Giuseppina Farina

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21 February 2020

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Asish K Ghosh

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21 February 2020

Swati Bhattacharyya

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21 February 2020

Jianxiu Yu

5

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21 February 2020

Bayar Thimmapaya

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21 February 2020

Jun Wei

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21 February 2020

John Varga

8

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21 February 2020

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publication date

10 January 2013

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21 February 2020

Journal of Investigative Dermatology

1 reference

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21 February 2020

133

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21 February 2020

5

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21 February 2020

1302-1310

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21 February 2020

describes a project that uses

1 reference

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

https://scigraph.springernature.com/pub.10.1038/jid.2012.479

0 references

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

p300/CBP and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

FIZZ1 stimulation of myofibroblast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Scleroderma and Smads: dysfunctional Smad family dynamics culminating in fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Factors involved in the regulation of type I collagen gene expression: implication in fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

CREB-binding protein and p300 in transcriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

CBP/p300 in cell growth, transformation, and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

29 September 2017

The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

27 June 2018

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

27 June 2018

Characterization of novel inhibitors of histone acetyltransferases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

5 September 2018

Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

5 September 2018

Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

5 September 2018

Conjunction dysfunction: CBP/p300 in human disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3626729

5 September 2018

Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast expression of the coactivator p300 governs the intensity of profibrotic response to transforming growth factor ?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression of p300 has an unfavorable impact on survival in resectable esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23303459

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/JID.2012.479

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303459%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303459%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303459%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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