(Q36773634)

English

Sterol biosynthesis inhibitors: potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase

scientific article published on 14 February 2007

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

Sterol biosynthesis inhibitors: potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase (English)

1 reference

Europe PubMed Central

16 August 2017

author name string

Zhihong Song

1

1 reference

Europe PubMed Central

16 August 2017

W David Nes

2

1 reference

Europe PubMed Central

16 August 2017

publication date

14 February 2007

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

42

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Europe PubMed Central

16 August 2017

1

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Europe PubMed Central

16 August 2017

15-33

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Europe PubMed Central

16 August 2017

https://scigraph.springernature.com/pub.10.1007/s11745-006-3017-1

0 references

Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of high energy intermediate analogues to study sterol biosynthesis in higher plants

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Azasteroids as antifungals

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple functions for sterols in Saccharomyces cerevisiae.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based active site modification of the soybean sterol methyltransferase by 26,27-dehydrocycloartenol

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cholesterol synthesis and cell growth by 24(R,S),25-iminolanosterol and triparanol in cultured rat hepatoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol phylogenesis and algal evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol methyltransferase: functional analysis of highly conserved residues by site-directed mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol methyl transferase: enzymology and inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional importance of structural features of ergosterol in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antifungal properties of solanum alkaloids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for transformation of substrates by the S-adenosyl-L-methionine:delta 24(25)-sterol methyltransferase. Inhibition by analogs of the transition state coordinate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the sterol binding site of soybean sterol methyltransferase by site-directed mutagenesis: functional analysis of conserved aromatic amino acids in Region 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol methyltransferase2: purification, properties, and inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of phytosterols. Kinetic mechanism for the enzymatic C-methylation of sterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemical specificity for sterols in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phytosterol biosynthesis pathway in Mortierella alpina

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active site mapping and substrate channeling in the sterol methyltransferase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol structure and membrane function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification, characterization and catalytic properties of human sterol 8-isomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol specificity of the Saccharomyces cerevisiae ERG6 gene product expressed in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme mechanisms for sterol C-methylations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based enzyme inactivators of phytosterol biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for similarities and differences in the biosynthesis of fungal sterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/17393207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11745-006-3017-1

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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