(Q36800979)

16 August 2017

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title

Innate immunity of the newborn: basic mechanisms and clinical correlates (English)

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16 August 2017

Ofer Levy

1

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16 August 2017

1 May 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

379-390

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16 August 2017

5

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Viral and bacterial pathogens at the maternal-fetal interface.

16 August 2017

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Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions.

31 March 2020

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Erythema toxicum neonatorum is an innate immune response to commensal microbes penetrated into the skin of the newborn infant

31 March 2020

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Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora

31 March 2020

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Neonatal adaptive immunity comes of age

31 March 2020

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Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates

31 March 2020

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Passive and active components of neonatal innate immune defenses

31 March 2020

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Innate immune recognition

31 March 2020

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Elevated circulating IL-1beta and TNF-alpha, and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome

31 March 2020

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Innate cellular immune responses in newborns

31 March 2020

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Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo

31 March 2020

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Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.

31 March 2020

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Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens

31 March 2020

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Vaccination in the neonatal period and early infancy

31 March 2020

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House dust extracts have both TH2 adjuvant and tolerogenic activities.

31 March 2020

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The effect of infections on susceptibility to autoimmune and allergic diseases

31 March 2020

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Renaissance of the hygiene hypothesis

31 March 2020

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Toll receptors in innate immunity

31 March 2020

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Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity

31 March 2020

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Mammalian Toll-like receptors

31 March 2020

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Antimicrobial polypeptides

31 March 2020

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Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes

31 March 2020

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Intervention of Toll-like receptor-mediated human innate immunity and inflammation by synthetic compounds and naturally occurring products

31 March 2020

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Cutaneous bacterial infections in the newborn

31 March 2020

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Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions.

31 March 2020

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Proteome analysis of vernix caseosa

31 March 2020

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Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response

31 March 2020

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TLR signaling in the gut in health and disease

31 March 2020

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Evidence for an innate immune response in the immature human intestine: toll-like receptors on fetal enterocytes

31 March 2020

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Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

31 March 2020

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Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells

31 March 2020

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Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis

31 March 2020

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Paneth cells and antibacterial host defense in neonatal small intestine

31 March 2020

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The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis

31 March 2020

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Necrotising enterocolitis

31 March 2020

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Protection of the neonate by the innate immune system of developing gut and of human milk

31 March 2020

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Breastfeeding: maintaining an irreplaceable immunological resource

31 March 2020

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Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk

31 March 2020

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Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.

31 March 2020

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Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both.

31 March 2020

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Ontogeny of Toll-like receptors Tlr2 and Tlr4 in mice

31 March 2020

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Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response.

31 March 2020

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By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide.

31 March 2020

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Expression and activity of beta-defensins and LL-37 in the developing human lung.

31 March 2020

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The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets

31 March 2020

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IL-6 is constitutively expressed during lung morphogenesis and enhances fetal lung explant branching.

31 March 2020

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Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dysplasia with metaanalytic techniques.

31 March 2020

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Characterization of the macrophage-stimulating activity from Ureaplasma urealyticum

31 March 2020

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Ureaplasma urealyticum modulates endotoxin-induced cytokine release by human monocytes derived from preterm and term newborns and adults

31 March 2020

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Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung.

31 March 2020

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FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation

31 March 2020

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Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults.

31 March 2020

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Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health

31 March 2020

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Change in IFN-gamma-producing capacity in early life and exposure to environmental microbes

31 March 2020

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Mechanisms of the hygiene hypothesis--molecular and otherwise

31 March 2020

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Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

31 March 2020

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

31 March 2020

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Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

31 March 2020

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Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord bloo

31 March 2020

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The complement system in B cell regulation

31 March 2020

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Influence of complement C3 amount on IgG responses in early life: immunization with C3b-conjugated antigen increases murine neonatal antibody responses

31 March 2020

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Fetal distress increases interleukin-6 and interleukin-8 and decreases tumour necrosis factor-alpha cord blood levels in noninfected full-term neonates

31 March 2020

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The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

31 March 2020

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Adenosine: an endogenous regulator of innate immunity

31 March 2020

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Erythema toxicum neonatorum: an immunohistochemical analysis

31 March 2020

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Age-dependent variation in the serum concentration of mannan-binding protein

31 March 2020

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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

31 March 2020

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C/EBPalpha is critical for the neonatal acute-phase response to inflammation

31 March 2020

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The inflammation-induced down-regulation of plasma Fetuin-A ( 2HS-Glycoprotein) in liver results from the loss of interaction between long C/EBP isoforms at two neighbouring binding sites

31 March 2020

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Modification of macrophage response to lipopolysaccharide by fetuin

31 March 2020

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The fetal glycoprotein, fetuin, counteracts ill-effects of the bacterial endotoxin, lipopolysaccharide, in pregnancy

31 March 2020

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Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan

31 March 2020

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Neutrophil production and function in newborn infants

31 March 2020

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Interaction of neonatal phagocytes with group B streptococcus: recognition and response

31 March 2020

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A mixed population of immature and mature leucocytes in umbilical cord blood results in a reduced expression and function of CR3 (CD11b/CD18)

31 March 2020

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Neutrophil adhesion molecules in term and premature infants: normal or enhanced leucocyte integrins but defective L-selectin expression and shedding

31 March 2020

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Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants.

31 March 2020

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Directing transition from innate to acquired immunity: defining a role for IL-6.

31 March 2020

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Oxidative Metabolism of Cord Blood Neutrophils: Relationship to Content and Degranulation of Cytoplasmic Granules

31 March 2020

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Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein.

31 March 2020

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Defective neutrophil oxidative burst in preterm newborns on exposure to coagulase-negative staphylococci

31 March 2020

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Role of protein tyrosine kinase p53/56lyn in diminished lipopolysaccharide priming of formylmethionylleucyl- phenylalanine-induced superoxide production in human newborn neutrophils

31 March 2020

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Phenotype of fetal monocytes and B lymphocytes during the third trimester of pregnancy

31 March 2020

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Development of the dendritic cell system during mouse ontogeny

31 March 2020

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Ontogeny and innate properties of neonatal dendritic cells

31 March 2020

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Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs.

31 March 2020

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CD1c(+) immature myeloid dendritic cells are predominant in cord blood of healthy neonates

31 March 2020

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

31 March 2020

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Characterization and partial purification of a macrophage-stimulating factor from Mycoplasma hominis

31 March 2020

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Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae

31 March 2020

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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

31 March 2020

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TLR11 activation of dendritic cells by a protozoan profilin-like protein.

31 March 2020

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Monocyte toll-like receptor 4 expression and LPS-induced cytokine production increase during gestational aging

31 March 2020

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Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide.

31 March 2020

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Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns

31 March 2020

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Cytosine-phosphate-guanine motifs fail to promote T-helper type 1-polarized responses in human neonatal mononuclear cells

31 March 2020

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Differential responses of cord and adult blood-derived dendritic cells to dying cells

31 March 2020

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Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization

31 March 2020

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Neonatal hypersusceptibility to endotoxin correlates with increased tumor necrosis factor production in mice

31 March 2020

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IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways

31 March 2020

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The Role of Toll‐Like Receptors in Herpes Simplex Infection in Neonates

31 March 2020

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Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice

31 March 2020

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Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

31 March 2020

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Acute lipopolysaccharide-mediated injury in neonatal white matter glia: role of TNF-alpha, IL-1beta, and calcium

31 March 2020

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Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain.

31 March 2020

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Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and

31 March 2020

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Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.

31 March 2020

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Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

31 March 2020

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A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells

31 March 2020

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Therapeutic potential of Toll-like receptor 9 activation

31 March 2020

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CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus.

31 March 2020

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Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release

31 March 2020

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Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes.

31 March 2020

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Genetic susceptibility to neonatal infection

31 March 2020

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Newer approaches to the diagnosis of early onset neonatal sepsis

31 March 2020

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Expression of toll-like receptors in neonatal sepsis

31 March 2020

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CpG oligodeoxynucleotides enhance neonatal resistance to Listeria infection.

31 March 2020

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Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice

31 March 2020

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Antimicrobial factors in the cervical mucus plug.

31 March 2020

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Toll-like receptor (TLR) expression and TLR-mediated cytokine/chemokine production by human uterine epithelial cells

31 March 2020

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Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C)

31 March 2020

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Divergent trophoblast responses to bacterial products mediated by TLRs

31 March 2020

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Apoptosis and its role in the trophoblast

31 March 2020

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Expression and subcellular localization of TLR-4 in term and first trimester human placenta.

31 March 2020

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Lipopolysaccharide-binding protein in microbial invasion of the amniotic cavity and human parturition.

31 March 2020

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Endotoxin-neutralizing antimicrobial proteins of the human placenta

31 March 2020

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Lactoferrin in intrauterine infection, human parturition, and rupture of fetal membranes

31 March 2020

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Elevations of group II phospholipase A2 concentrations in serum and amniotic fluid in association with preterm labor

31 March 2020

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Mobilization of potent plasma bactericidal activity during systemic bacterial challenge. Role of group IIA phospholipase A2.

31 March 2020

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Antimicrobial activity of amniotic fluid in South Indian women

31 March 2020

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Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense

31 March 2020

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The chemokine connection: hormonal and embryonic regulation at the human maternal-embryonic interface--a review

31 March 2020

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The role of CCL21 in recruitment of T-precursor cells to fetal thymi

31 March 2020

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Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system.

31 March 2020

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Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

31 March 2020

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Delayed inflammatory response to Pneumocystis carinii infection in neonatal mice is due to an inadequate lung environment

31 March 2020

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Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-alpha) in preterm and term neonates

31 March 2020

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Differential Expression of Chemokines and Their Receptors in Adult and Neonatal Macrophages Infected with Human or Avian Influenza Viruses

31 March 2020

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Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission

31 March 2020

1 reference

IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants

31 March 2020

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Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication.

31 March 2020

1 reference

Reduced secretion of interleukin-1 and tumor necrosis factor-alpha by neonatal monocytes

31 March 2020

1 reference

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

31 March 2020

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Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies

31 March 2020

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Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood

31 March 2020

1 reference

Diminished priming of neonatal polymorphonuclear leukocytes by lipopolysaccharide is associated with reduced CD14 expression.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2075

1 reference

16 August 2017

1 reference

PubMed ID

17457344