(Q36807931)

English

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

scientific article published on 16 May 2008

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scholarly article

1 reference

Europe PubMed Central

16 August 2017

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis (English)

1 reference

Europe PubMed Central

16 August 2017

0 references

author name string

John J Lehman

1

1 reference

Europe PubMed Central

16 August 2017

Sihem Boudina

2

1 reference

Europe PubMed Central

16 August 2017

Natasha Hausler Banke

3

1 reference

Europe PubMed Central

16 August 2017

Nandakumar Sambandam

4

1 reference

Europe PubMed Central

16 August 2017

Xianlin Han

5

1 reference

Europe PubMed Central

16 August 2017

Deanna M Young

6

1 reference

Europe PubMed Central

16 August 2017

Teresa C Leone

7

1 reference

Europe PubMed Central

16 August 2017

Richard W Gross

8

1 reference

Europe PubMed Central

16 August 2017

E Douglas Lewandowski

9

1 reference

Europe PubMed Central

16 August 2017

E Dale Abel

10

1 reference

Europe PubMed Central

16 August 2017

Daniel P Kelly

11

1 reference

Europe PubMed Central

16 August 2017

publication date

16 May 2008

1 reference

Europe PubMed Central

16 August 2017

American Journal of Physiology Heart and Circulatory Physiology

1 reference

Europe PubMed Central

16 August 2017

295

1 reference

Europe PubMed Central

16 August 2017

1

1 reference

Europe PubMed Central

16 August 2017

H185-96

1 reference

Europe PubMed Central

16 August 2017

The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

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A fundamental system of cellular energy homeostasis regulated by PGC-1alpha

1 reference

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

1 reference

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Oxidative phosphorylation and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

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Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha

1 reference

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Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice

1 reference

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29 September 2017

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

1 reference

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29 September 2017

PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

1 reference

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29 September 2017

Mitochondrial energy metabolism in heart failure: a question of balance

1 reference

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29 September 2017

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Mitochondria, oxidants, and aging

1 reference

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29 September 2017

Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry

1 reference

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29 September 2017

Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

1 reference

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29 September 2017

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Nuclear activators and coactivators in mammalian mitochondrial biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Coupling of mitochondrial fatty acid uptake to oxidative flux in the intact heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes

1 reference

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29 September 2017

Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

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A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

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29 September 2017

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

Peroxisome proliferator-activated receptors: nuclear control of metabolism

1 reference

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29 September 2017

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

29 September 2017

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

1 reference

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29 September 2017

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 reference

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29 September 2017

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

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29 September 2017

Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts

1 reference

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29 September 2017

Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters

1 reference

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29 September 2017

DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

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A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

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PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

27 June 2018

Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

27 June 2018

Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13C NMR spectroscopy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

27 June 2018

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

The cristal membrane of mitochondria is the principal site of oxidative phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2494758

5 September 2018

Triacylglycerol turnover in isolated working hearts of acutely diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of energy metabolism of the heart during acute increase in heart work

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial ATP synthesis in permeabilized cells: assessment of the ATP/O values in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose and fatty acid metabolism in the isolated working mouse heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial Oxygen Consumption Is Unchanged but Efficiency Is Reduced in Patients With Essential Hypertension and Left Ventricular Hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal triglyceride transfer protein gene expression and triglyceride accumulation in hypoxic human hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPHEART.00081.2008

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

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