(Q36814743)

16 August 2017

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title

Phospholipid-mediated signaling systems as novel targets for treatment of heart disease (English)

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16 August 2017

Paramjit S Tappia

1

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16 August 2017

publication date

1 January 2007

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Canadian Journal of Physiology and Pharmacology

16 August 2017

published in

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16 August 2017

volume

85

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16 August 2017

issue

1

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16 August 2017

page(s)

25-41

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Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo.

16 August 2017

cites work

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Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review

21 January 2018

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Inhibition of PLC improves postischemic recovery in isolated rat heart

21 January 2018

1 reference

Regulation of cardiac sarcolemmal Na+/H+ exchanger activity: potential pathophysiological significance of endogenous mediators and oxidant stress

21 January 2018

1 reference

Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiomyocytes via P2Y11-like receptors

21 January 2018

1 reference

The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes.

21 January 2018

1 reference

Apoptosis in the heart: when and why?

21 January 2018

1 reference

Release of choline in the isolated heart, an indicator of ischemic phospholipid degradation and its protection by ischemic preconditioning: no evidence for a role of phospholipase D.

21 January 2018

1 reference

Anionic phospholipids, interfacial binding and the regulation of cell functions

21 January 2018

1 reference

Nuclear phospholipase C and signaling

21 January 2018

1 reference

A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure

21 January 2018

1 reference

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

21 January 2018

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Transgenic Galphaq overexpression induces cardiac contractile failure in mice

21 January 2018

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Diacylglycerol causes major structural transitions in phospholipid bilayer membranes

21 January 2018

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Modification by diacylglycerol of the structure and interaction of various phospholipid bilayer membranes

21 January 2018

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Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload

21 January 2018

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Expression of phospholipase D isozymes in scar and viable tissue in congestive heart failure due to myocardial infarction.

21 January 2018

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Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload

21 January 2018

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Subcellular basis of cardiac contractile failure

21 January 2018

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Calcium movements in relation to heart function

21 January 2018

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Phosphatidic acid: a potential signal transducer for cardiac hypertrophy

21 January 2018

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Status of myocardial antioxidants in ischemia-reperfusion injury

21 January 2018

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Role of oxidative stress in cardiovascular diseases

21 January 2018

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21 January 2018

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Exploration of the possible roles of phospholipase D and protein kinase C in the mechanism of ischemic preconditioning in the myocardium

21 January 2018

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Recent developments in proteomics: implications for the study of cardiac hypertrophy and failure

21 January 2018

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Altered myocardial mechanics in diabetic rats

21 January 2018

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Oxygen free radicals and myocardial damage: protective role of thiol-containing agents

21 January 2018

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Phospholipase D structure and regulation

21 January 2018

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Structure, regulation, and function of phospholipase C isozymes

21 January 2018

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Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.

21 January 2018

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Intracellular Ca2+ and adrenergic responsiveness of cardiac myocytes in streptozotocin-induced diabetes

21 January 2018

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Effective protection by NHE-1 inhibition in ischemic and reperfused heart under preconditioning blockade

21 January 2018

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A new approach to the development of anti-ischemic drugs. Substances that counteract the deleterious effect of lysophosphatidylcholine on the heart

21 January 2018

1 reference

Diabetic cardiomyopathy: mechanisms, diagnosis and treatment.

21 January 2018

1 reference

Reperfusion induced injury: manifestations, mechanisms, and clinical relevance

21 January 2018

1 reference

Signaling pathways in cardiac myocyte hypertrophy

21 January 2018

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Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2.

21 January 2018

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Regulatory mechanism and physiological role of cytosolic phospholipase A2

21 January 2018

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Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

21 January 2018

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Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

21 January 2018

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

21 January 2018

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Glutathionylation of mitochondrial proteins

21 January 2018

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Molecular cloning and characterization of a novel phospholipase C, PLC-eta

21 January 2018

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Transglutaminase II: a new class of GTP-binding protein with new biological functions

21 January 2018

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Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

21 January 2018

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The cell biology of acute myocardial ischemia

21 January 2018

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Relation between glycolysis and calcium homeostasis in postischemic myocardium

21 January 2018

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Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C.

21 January 2018

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Novel mechanisms mediating stunned myocardium

21 January 2018

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Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

21 January 2018

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Human cardiac phospholipase D activity is tightly controlled by phosphatidylinositol 4,5-bisphosphate

21 January 2018

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Phospholipase A2-mediated activation of phospholipase D in rat heart sarcolemma

21 January 2018

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A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

21 January 2018

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Angiotensin II promotes glucose-induced activation of cardiac protein kinase C isozymes and phosphorylation of troponin I.

21 January 2018

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Molecular biology of protein kinase C signaling in cardiac myocytes

21 January 2018

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Inhibition of phospholipase C-gamma 1 augments the decrease in cardiomyocyte viability by H2O2.

21 January 2018

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Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms

21 January 2018

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Role and regulation of phospholipase D signalling

21 January 2018

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Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

21 January 2018

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Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype

21 January 2018

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Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

21 January 2018

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Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.

21 January 2018

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Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats

21 January 2018

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Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}

21 January 2018

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Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats

21 January 2018

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Enhanced phosphodiesteratic breakdown and turnover of phosphoinositides during reperfusion of ischemic rat heart

21 January 2018

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Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants: can caffeic acid phenethyl ester (CAPE) protect the heart?

21 January 2018

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Phospholipase D activity in subcellular membranes of rat ventricular myocardium

21 January 2018

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Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy

21 January 2018

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Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

21 January 2018

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Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner

21 January 2018

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Distinct characteristic of Galpha(h) (transglutaminase II) by compartment: GTPase and transglutaminase activities

21 January 2018

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Upregulation of phospholipase d expression and activation in ventricular pressure-overload hypertrophy

21 January 2018

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Alterations in Ca2+ binding by and composition of the cardiac sarcolemmal membrane in chronic diabetes

21 January 2018

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Cellular mechanisms of ischemia-reperfusion injury

21 January 2018

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Signalling by protein kinase C isoforms in the heart

21 January 2018

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Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts

21 January 2018

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Congestive heart failure in the diabetic

21 January 2018

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Regulation of phosphoinositide-specific phospholipase C

21 January 2018

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Regulation of phosphoinositide-specific phospholipase C isozymes

21 January 2018

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Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells

21 January 2018

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Diabetic cardiomyopathy: where are we 40 years later?

21 January 2018

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Phospholipase C may be involved in norepinephrine-induced cardiac hypertrophy

21 January 2018

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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization

21 January 2018

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Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.

21 January 2018

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Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

21 January 2018

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The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.

21 January 2018

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Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics

21 January 2018

1 reference

A novel intracellular membrane-bound calcium-independent phospholipase A(2)

21 January 2018

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Depressed responsiveness of phospholipase C isoenzymes to phosphatidic acid in congestive heart failure

21 January 2018

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Defective phosphatidic acid-phospholipase C signaling in diabetic cardiomyopathy

21 January 2018

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Oxidative stress and redox regulation of phospholipase D in myocardial disease

21 January 2018

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Role of oxidants in the signaling pathway of preconditioning

21 January 2018

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Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.

21 January 2018

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Growth and hypertrophy of the heart: towards an understanding of cardiac specific and inducible gene expression

21 January 2018

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Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy

21 January 2018

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PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling

21 January 2018

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The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart

21 January 2018

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Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

21 January 2018

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Angiotensin II signaling pathways mediated by tyrosine kinases.

21 January 2018

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Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure

21 January 2018

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Modulation of ICa-L by alpha1-adrenergic stimulation in rat ventricular myocytes

21 January 2018

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Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy

21 January 2018

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Low level of sarcolemmal phosphatidylinositol 4,5-bisphosphate in cardiomyopathic hamster (UM-X7.1) heart

21 January 2018

1 reference

Expression of G qα and PLC-β in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction

21 January 2018

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Molecular Defects in Sarcolemmal Glycerophospholipid Subclasses in Diabetic Cardiomyopathy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y06-098

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16 August 2017

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