(Q36814772)

16 August 2017

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title

Type 2 diabetes and cardiovascular disease: getting to the fat of the matter (English)

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16 August 2017

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cardiovascular disease

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Kerry B Goralski

1

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16 August 2017

Christopher J Sinal

series ordinal

2

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16 August 2017

publication date

1 January 2007

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Canadian Journal of Physiology and Pharmacology

16 August 2017

published in

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16 August 2017

volume

85

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16 August 2017

issue

1

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16 August 2017

page(s)

113-132

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Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes

16 August 2017

cites work

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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

21 January 2018

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Visfatin--a true or false trail to type 2 diabetes mellitus.

21 January 2018

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Impaired fibrinolytic compensation for hypercoagulability in obese patients with type 2 diabetes: association with increased plasminogen activator inhibitor-1.

21 January 2018

1 reference

Regulation of fasted blood glucose by resistin

21 January 2018

1 reference

Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome

21 January 2018

1 reference

Plasma visfatin concentrations and fat depot-specific mRNA expression in humans

21 January 2018

1 reference

Effects of etanercept in patients with the metabolic syndrome

21 January 2018

1 reference

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

21 January 2018

1 reference

Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Québec Family Study

21 January 2018

1 reference

Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease.

21 January 2018

1 reference

Pituitary resistin gene expression is upregulated in vitro and in vivo by dexamethasone but is unaffected by rosiglitazone

21 January 2018

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Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression.

21 January 2018

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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

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Prevalence of overweight and obesity in a provincial population of Canadian preschool children

21 January 2018

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Brown adipose tissue: function and physiological significance

21 January 2018

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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

21 January 2018

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Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

21 January 2018

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

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Effect of PPAR-alpha and -gamma agonist on the expression of visfatin, adiponectin, and TNF-alpha in visceral fat of OLETF rats

21 January 2018

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Critical review of acylation-stimulating protein physiology in humans and rodents

21 January 2018

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Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance

21 January 2018

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Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children

21 January 2018

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21 January 2018

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

21 January 2018

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Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors

21 January 2018

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Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

21 January 2018

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Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin

21 January 2018

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Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

21 January 2018

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Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumour necrosis factor

21 January 2018

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From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes.

21 January 2018

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The role of sex in cardiac function and disease

21 January 2018

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Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity

21 January 2018

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Decreased plasma concentration of a novel anti-inflammatory protein--adiponectin--in hypertensive men with coronary artery disease.

21 January 2018

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Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans

21 January 2018

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Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes

21 January 2018

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Tissue-specific nutritional regulation of angiotensinogen in adipose tissue

21 January 2018

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Leptin and the regulation of body weight in mammals

21 January 2018

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Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues

21 January 2018

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RETRACTED: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin

21 January 2018

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Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies

21 January 2018

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The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications.

21 January 2018

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Adiponectin: A novel adipokine linking adipocytes and vascular function

21 January 2018

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Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects

21 January 2018

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Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding

21 January 2018

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Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

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Visfatin is an adipokine, but it is not regulated by thiazolidinediones

21 January 2018

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

21 January 2018

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Interleukin-6 and the acute phase response

21 January 2018

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Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

21 January 2018

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

21 January 2018

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

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AdipoQ is a novel adipose-specific gene dysregulated in obesity

21 January 2018

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Modulation of circulating leptin levels by its soluble receptor

21 January 2018

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Relationship between changes in serum leptin levels and blood pressure after weight loss

21 January 2018

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Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors

21 January 2018

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Resistin gene expression in human adipocytes is not related to insulin resistance.

21 January 2018

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The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein

21 January 2018

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C5L2 is a functional receptor for acylation-stimulating protein

21 January 2018

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Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone

21 January 2018

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Improvement by the insulin-sensitizing agent, troglitazone, of abnormal fibrinolysis in type 2 diabetes mellitus.

21 January 2018

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Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressure

21 January 2018

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Troglitazone reduces plasma levels of tumour necrosis factor-alpha in obese patients with type 2 diabetes.

21 January 2018

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The economic costs associated with physical inactivity and obesity in Canada: an update

21 January 2018

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Prevalence of class I, II and III obesity in Canada

21 January 2018

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The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

21 January 2018

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Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

21 January 2018

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Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma

21 January 2018

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Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

21 January 2018

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Interleukin-6 depletion selectively improves hepatic insulin action in obesity

21 January 2018

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

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Plasminogen-activator inhibitor type 1 and coronary artery disease

21 January 2018

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Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1.

21 January 2018

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Adipokines: molecular links between obesity and atheroslcerosis

21 January 2018

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Abnormal splicing of the leptin receptor in diabetic mice

21 January 2018

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Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects

21 January 2018

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Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy

21 January 2018

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Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue

21 January 2018

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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 January 2018

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cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).

21 January 2018

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Analysis of an expression profile of genes in the human adipose tissue

21 January 2018

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Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

21 January 2018

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PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

21 January 2018

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Novel roles for acylation stimulating protein/C3adesArg: a review of recent in vitro and in vivo evidence

21 January 2018

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Differentiation between obesity and insulin resistance in the association with C-reactive protein

21 January 2018

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Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

21 January 2018

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Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

21 January 2018

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Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha

21 January 2018

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Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

21 January 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

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Resistin expression and regulation in mouse pituitary

21 January 2018

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Pituitary resistin gene expression: effects of age, gender and obesity

21 January 2018

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Leptin impairs metabolic actions of insulin in isolated rat adipocytes.

21 January 2018

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21 January 2018

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Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice.

21 January 2018

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Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle

21 January 2018

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Plasma adrenomedullin levels in patients with non-insulin dependent diabetes mellitus: close relationships with diabetic complications

21 January 2018

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Expression of the adrenomedullin gene in adipose tissue

21 January 2018

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Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein

21 January 2018

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Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds.

21 January 2018

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Leptin-replacement therapy for lipodystrophy.

21 January 2018

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Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy.

21 January 2018

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Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice

21 January 2018

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Towards a pro-inflammatory and immunomodulatory emerging role of leptin

21 January 2018

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Leptin: a metabolic hormone that functions like a proinflammatory adipokine.

21 January 2018

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Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

21 January 2018

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Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

21 January 2018

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Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin

21 January 2018

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Detection and quantification of the control proteins of the alternative pathway of complement in 3T3-L1 adipocytes

21 January 2018

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Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

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Epidemiology of obesity in the United States

21 January 2018

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"Who is the wise man?--The one who foresees consequences:". Childhood obesity, new associated comorbidity and prevention

21 January 2018

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Plasma adiponectin levels and risk of myocardial infarction in men.

21 January 2018

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An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance.

21 January 2018

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Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss

21 January 2018

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Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Ph

21 January 2018

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Measuring the full economic costs of diet, physical activity and obesity-related chronic diseases.

21 January 2018

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Adiponectin acts in the brain to decrease body weight.

21 January 2018

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Women and ischemic heart disease: pathophysiologic implications from the Women's Ischemia Syndrome Evaluation (WISE) Study and future research steps

21 January 2018

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The insulin resistance syndrome

21 January 2018

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Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue

21 January 2018

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High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: from concept to clinical practice to clinical benefit

21 January 2018

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Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

21 January 2018

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Raised interleukin-6 levels in obese patients

21 January 2018

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Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide

21 January 2018

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Tissue factor gene expression in the adipose tissues of obese mice

21 January 2018

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Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome

21 January 2018

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Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

21 January 2018

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Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta

21 January 2018

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

21 January 2018

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Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

21 January 2018

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Acylation-stimulating protein: effect of acute exercise and endurance training.

21 January 2018

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Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus

21 January 2018

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Hypoadiponectinemia is closely linked to endothelial dysfunction in man.

21 January 2018

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Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity

21 January 2018

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Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress

21 January 2018

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Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway.

21 January 2018

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Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway.

21 January 2018

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Relationship between IL-6, leptin and adiponectin and variables of fibrinolysis in overweight and obese hypertensive patients.

21 January 2018

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A promoter genotype and oxidative stress potentially link resistin to human insulin resistance

21 January 2018

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An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity

21 January 2018

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Resistin and obesity-associated insulin resistance

21 January 2018

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The hormone resistin links obesity to diabetes

21 January 2018

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Evidence for the involvement of interleukin 6 in experimental cancer cachexia

21 January 2018

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Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome

21 January 2018

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Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis.

21 January 2018

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Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line

21 January 2018

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Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

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Central administration of resistin promotes short-term satiety in rats.

21 January 2018

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Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin

21 January 2018

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Diet-induced obese mice develop peripheral, but not central, resistance to leptin

21 January 2018

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Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

21 January 2018

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Interleukin-6-deficient mice develop mature-onset obesity

21 January 2018

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Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity

21 January 2018

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Adiponectin--a key adipokine in the metabolic syndrome

21 January 2018

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Hypothalamic resistin immunoreactivity is reduced by obesity in the mouse: co-localization with alpha-melanostimulating hormone

21 January 2018

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21 January 2018

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Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice

21 January 2018

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Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance

21 January 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

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Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes

21 January 2018

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

21 January 2018

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

21 January 2018

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

21 January 2018

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Comparative studies of resistin expression and phylogenomics in human and mouse

21 January 2018

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

21 January 2018

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Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes

21 January 2018

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Effect of acylation stimulating protein on the triacylglycerol synthetic pathway of human adipose tissue.

21 January 2018

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Differential effects of peroxisome proliferator-activated receptor ligands and sulfonylurea plus statin treatment on plasma concentrations of adipokines in type 2 diabetes with dyslipidemia

21 January 2018

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The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects

21 January 2018

1 reference

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

21 January 2018

1 reference

Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo-controlled trial

21 January 2018

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

21 January 2018

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Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year

21 January 2018

1 reference

Human Resistin Gene: Molecular Scanning and Evaluation of Association with Insulin Sensitivity and Type 2 Diabetes in Caucasians

21 January 2018

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Risks and consequences of childhood and adolescent obesity

21 January 2018

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TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis

21 January 2018

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The indirect costs of obesity to society

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y06-092

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16 August 2017

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